Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles
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Tartalom: http://real.mtak.hu/40479/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles
Létrehozó:
Gyulai, Gergő
Magyar, Anna
Rohonczy, János
Orosz, János
Yamasaki, Marcelo
BĹ‘sze, Szilvia
Kiss, Éva
Kiadó:
Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics
Dátum:
2016
Téma:
QD01 Analytical chemistry / analitikai kémia
QD04 Organic chemistry / szerves kémia
Tartalmi leírás:
Biodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug delivery the end group derivative of Pluronics was synthesized in a straightforward way to obtain Pluronic-amines. The formation of functional amine groups was confirmed by fluorescamine method and NMR analysis of their Boc-Phe-OH and Fmoc-Phe-OH conjugates. Pluronic and Pluronic-amine stabilized PLGA NPs prepared by nanoprecipitation were characterized by dynamic light scattering and zeta potential measurements. All of the systems showed high colloidal stability checked by electrolyte induced aggregation, although the presence of Pluronic-amine on the surface decreased the zeta potential in some extent. The introduction of reactive primary amine groups into the surface layer of PLGA NPs while preserving the aggregation stability, provides a possibility for coupling of various ligands allowing targeted delivery and also contributes to the improved membrane affinity of NPs.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Gyulai, Gergő and Magyar, Anna and Rohonczy, János and Orosz, János and Yamasaki, Marcelo and Bősze, Szilvia and Kiss, Éva (2016) Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles. Express Polymer Letters, 10 (3). p. 216. ISSN 1788618X
Kapcsolat:
10.3144/expresspolymlett.2016.20