Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse. (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.

Metaadatok

Tartalom:	http://real.mtak.hu/74667/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.
Létrehozó:	HorvÃ¡th, ÃdÃ¡m Menghis, Awt Botz, BÃ¡lint BorbÃ©ly, Ã‰va KemÃ©ny, Ãgnes TÃ©kus, ValÃ©ria Csepregi, Janka ZsÃ³fia MÃ³csai, Attila JuhÃ¡sz, TamÃ¡s ZÃ¡kÃ¡ny, RÃ³za BogdÃ¡n, DÃ³ra MÃ¡tyus, PÃ©ter Keeble, Julie PintÃ©r, Erika Helyes, Zsuzsanna
Kiadó:	Nature Publishing Group
Dátum:	2017
Téma:	R850-854 Experimental medicine / kisÃ©rleti orvostudomÃ¡ny
Tartalmi leírás:	Semicarbazide-sensitive amine oxidase (SSAO) catalyses oxidative deamination of primary amines. Since there is no data about its function in pain and arthritis mechanisms, we investigated the effects of our novel SSAO inhibitor SzV-1287 in chronic mouse models of joint inflammation. Effects of SzV-1287 (20 mg/kg i.p./day) were investigated in the K/BxN serum-transfer and complete Freund's adjuvant (CFA)-evoked active immunization models compared to the reference SSAO inhibitor LJP-1207. Mechanonociception was assessed by aesthesiometry, oedema by plethysmometry, clinical severity by scoring, joint function by grid test, myeloperoxidase activity by luminescence, vascular leakage by fluorescence in vivo imaging, histopathological changes by semiquantitative evaluation, and cytokines by Luminex assay. SzV-1287 significantly inhibited hyperalgesia and oedema in both models. Plasma leakage and keratinocyte chemoattractant production in the tibiotarsal joint, but not myeloperoxidase activity was significantly reduced by SzV-1287 in K/BxN-arthritis. SzV-1287 did not influence vascular and cellular mechanisms in CFA-arthritis, but significantly decreased histopathological alterations. There was no difference in the anti-hyperalgesic and anti-inflammatory actions of SzV-1287 and LJP-1207, but only SzV-1287 decreased CFA-induced tissue damage. Unlike SzV-1287, LJP-1207 induced cartilage destruction, which was confirmed in vitro. SzV-1287 exerts potent analgesic and anti-inflammatory actions in chronic arthritis models of distinct mechanisms, without inducing cartilage damage.
Nyelv:	angol
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text
Azonosító:	http://real.mtak.hu/74667/1/srep39863.pdf HorvÃ¡th, ÃdÃ¡m and Menghis, Awt and Botz, BÃ¡lint and BorbÃ©ly, Ã‰va and KemÃ©ny, Ãgnes and TÃ©kus, ValÃ©ria and Csepregi, Janka ZsÃ³fia and MÃ³csai, Attila and JuhÃ¡sz, TamÃ¡s and ZÃ¡kÃ¡ny, RÃ³za and BogdÃ¡n, DÃ³ra and MÃ¡tyus, PÃ©ter and Keeble, Julie and PintÃ©r, Erika and Helyes, Zsuzsanna (2017) Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse. SCIENTIFIC REPORTS, 7. pp. 1-13. ISSN 2045-2322
Kapcsolat:	http://real.mtak.hu/74667/ https://doi.org/10.1038/srep39863 MTMT:3166279; doi:10.1038/srep39863