Zonda is a novel early component of the autophagy pathway in Drosophila
  • Metaadatok
Tartalom: http://real.mtak.hu/73485/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Zonda is a novel early component of the autophagy pathway in Drosophila
Létrehozó:
Melani, Mariana
Valko, Ayelén
Romero, Nuria M.
Aguilera, Milton O.
Acevedo, Julieta M.
Juhász, Gábor
Kiadó:
American Society for Cell Biology
Dátum:
2017
Téma:
QH301 Biology / biolĂłgia
QH3015 Molecular biology / molekuláris biológia
Tartalmi leírás:
Autophagy is an evolutionary conserved process by which eukaryotic cells undergo self-digestion of cytoplasmic components. Here we report that a novel Drosophila immunophilin, which we have named Zonda, is critically required for starvation-induced autophagy. We show that Zonda operates at early stages of the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition. Zonda displays an even distribution under basal conditions, and soon after starvation nucleates in endoplasmic reticulum-associated foci that colocalize with omegasome markers. Zonda nucleation depends on Atg1, Atg13 and Atg17 but does not require Vps34, Vps15, Atg6 or Atg14. Zonda interacts physically with ATG1 through its kinase domain, as well as with ATG6 and Vps34. We propose that Zonda is an early component of the autophagy cascade necessary for Vps34-dependent PI3P deposition and omegasome formation.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Melani, Mariana and Valko, Ayelén and Romero, Nuria M. and Aguilera, Milton O. and Acevedo, Julieta M. and Juhász, Gábor (2017) Zonda is a novel early component of the autophagy pathway in Drosophila. MOLECULAR BIOLOGY OF THE CELL, 28 (22). pp. 3070-3081. ISSN 1059-1524
Kapcsolat:
MTMT:3275069; doi:10.1091/mbc.E16-11-0767