The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
  • Metaadatok
Tartalom: http://real.mtak.hu/73287/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
Létrehozó:
Rusz, Orsolya
Pál, Margit
Szilágyi, Éva
Rovó, László
Varga, Zoltán
Gyaponyi-Tomisa, Bernadett
Fábián, Gabriella
Kovács, Levente
Nagy, Olga
MĂłzes, Petra
Reisz, Zita
Tiszlavicz, László
Deák, Péter
Kahán, Zsuzsanna
Kiadó:
Springer Netherlands
Dátum:
2017
Téma:
RB Pathology / patolĂłgia, kĂłrtan
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolĂłgia
Tartalmi leírás:
DNA damage response failure may influence the efficacy of DNA-damaging treatments. We determined the expression of 16 genes involved in distinct DNA damage response pathways, in association with the response to standard therapy. Twenty patients with locoregionally advanced, squamous cell head and neck carcinoma were enrolled. The treatment included induction chemotherapy (iChT) with docetaxel, cisplatin and 5-fluorouracil followed by concomitant chemoradiotherapy (ChRT) or radiotherapy (RT) alone. The volumetric metabolic therapeutic response was determined by [18F]FDG-PET/CT. In the tumor and matched normal tissues collected before treatment, the gene expressions were examined via the quantitative real-time polymerase chain reaction (qRT-PCR). The down-regulation of TP53 was apparently associated with a poor response to iChT, its up-regulation with complete regression in 2 cases. 7 cases with down-regulated REV1 expression showed complete regression after ChRT/RT, while 1 case with REV1 overexpression was resistant to RT. The overexpression of WRN was an independent predictor of tumor relapse. Our results suggest that an altered expression of REV1 predicts sensitivity to RT, while WRN overexpression is an unfavorable prognostic factor.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Rusz, Orsolya and Pál, Margit and Szilágyi, Éva and Rovó, László and Varga, Zoltán and Gyaponyi-Tomisa, Bernadett and Fábián, Gabriella and Kovács, Levente and Nagy, Olga and Mózes, Petra and Reisz, Zita and Tiszlavicz, László and Deák, Péter and Kahán, Zsuzsanna (2017) The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors. PATHOLOGY AND ONCOLOGY RESEARCH, 23 (2). pp. 253-264. ISSN 1219-4956
Kapcsolat:
https://doi.org/10.1007/s12253-016-0088-z
MTMT:3118609; doi:10.1007/s12253-016-0088-z