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Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases

  • Metaadatok
Tartalom: http://real.mtak.hu/71034/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases
Létrehozó:
Wilhelm, Imola Mária
Fazakas, Csilla
Molnár, Kinga
VĂ©gh, Attila Gergely
Haskó, János
Krizbai, István Adorján
Kiadó:
Nature Publishing Group
Dátum:
2017
Téma:
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolĂłgia
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Tartalmi leírás:
Despite the potential obstacle represented by the blood-brain barrier for extravasating malignant cells, metastases are more frequent than primary tumors in the central nervous system. Not only tightly interconnected endothelial cells can hinder metastasis formation, other cells of the brain microenvironment (like astrocytes and microglia) can also be very hostile, destroying the large majority of metastatic cells. However, malignant cells that are able to overcome these harmful mechanisms may benefit from the shielding and even support provided by cerebral endothelial cells, astrocytes and microglia, rendering the brain a sanctuary site against anti-tumor strategies. Thus, cells of the neurovascular unit have a Janus-faced attitude towards brain metastatic cells, being both destructive and protective. In this review, we present the main mechanisms of brain metastasis formation, including those involved in extravasation through the brain vasculature and survival in the cerebral environment.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Wilhelm, Imola Mária and Fazakas, Csilla and Molnár, Kinga and Végh, Attila Gergely and Haskó, János and Krizbai, István Adorján (2017) Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. ISSN 0271-678X
Kapcsolat:
https://doi.org/10.1177/0271678X17732025
MTMT:3277912; doi:10.1177/0271678X17732025