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A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)

  • Metaadatok
Tartalom: http://real.mtak.hu/70598/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)
Létrehozó:
Polyák, Péter
Szemerszki, DĂłra
Benke, Henrik
Pukánszky, Béla
Kiadó:
Elsevier
Dátum:
2017-10
Téma:
Q1 Science (General) / természettudomány általában
QD Chemistry / kémia
QD02 Physical chemistry / fizikai kémia
Tartalmi leírás:
A novel approach is proposed for the determination of the diffusion coefficient of certain drugs in amorphous poly(hydroxybutyrate) (PHB), which can be a reliable alternative to the conventional permeation based measurements. The method requires the preparation of PHB films with various concentrations of the drug and if the latter absorbs in the visible wavelength range, its concentration gradient in the polymer film as well as the time dependence of the latter can be analyzed quantitatively by following changes in color. Color can be converted into concentration with the help of adequate calibration and thus the dependence of additive concentration on space (x) and time (t), i.e. the c(x,t) function, can be determined relatively easily. The fitting of the numerical solution of Fick's second law onto the measured values provides directly the targeted diffusion coefficient. The comparison of diffusion coefficients obtained by the proposed approach to values published in the literature proved that the new method provides reliable results and requires reasonable time and effort at the same time.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Polyák, Péter and Szemerszki, Dóra and Benke, Henrik and Pukánszky, Béla (2017) A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate). Polymer Testing, 63. pp. 342-348. ISSN 0142-9418, ESSN: 1873-234
Kapcsolat:
https://doi.org/10.1016/j.polymertesting.2017.08.037