Acetylsalicylic acid decreases the labeling of blood constituents with technetium-99m
  • Metaadatok
Tartalom: http://real.mtak.hu/70121/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Acetylsalicylic acid decreases the labeling of blood constituents with technetium-99m
Létrehozó:
Fonseca, A.
Frydman, J.
Rocha, Vanessa
Bernardo-Filho, M.
Kiadó:
Akadémiai Kiadó
Dátum:
2007
info:eu-repo/date/embargoEnd/2027-06-30
Téma:
QH Natural history / természetrajz
Tartalmi leírás:
Acetylsalicylic acid is the most widely used drug as antipyretic, analgesic, anti-inflammatory agent and
for secondary prevention of thrombotic phenomena in the heart, brain and peripheral circulation. Drugs
can modify the labeling of blood constituents with technetium-99m (
99m
Tc). This work has evaluated the
effect of
in vivo
treatment with acetylsalicylic acid on the
in vitro
labeling of the blood constituents with
99m
Tc. Wistar rats were treated with different doses (1.5, 3.0 and 6.0 mg/kg) of acetylsalicylic acid dur-
ing 1 hour. At higher dose used (6.0 mg/kg) animals were treated during different period of time (0.25,
1.0 and 4.0 hours). Animals treated with physiologic saline solution were used as control. After the
labeled process; plasma (P), blood cells (BC), insoluble (IF-P, IF-BC) and soluble (SF-P, SF-BC) frac-
tions were separated. Afterwards, the percentage of radioactivity (%ATI) in each fraction was calculat-
ed. The treatment during 1 hour with acetylsalicylic acid at higher dose has significantly (p < 0.05) mod-
ified the fixation of
99m
Tc on blood cells. Considering the results, we suggest that acetylsalicylic acid
used at therapeutic doses may interfere with the nuclear medicine procedures related to these blood con-
stituents.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Fonseca, A. and Frydman, J. and Rocha, Vanessa and Bernardo-Filho, M. (2007) Acetylsalicylic acid decreases the labeling of blood constituents with technetium-99m. Acta Biologica Hungarica, 58 (2). pp. 187-198. ISSN 0236-5383
Kapcsolat:
https://doi.org/10.1556/ABiol.58.2007.2.5
Létrehozó:
info:eu-repo/semantics/embargoedAccess