A novel aspect of NADPH production in ageing Penicilliumchrysogenum
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Tartalom: http://real.mtak.hu/70060/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
A novel aspect of NADPH production in ageing Penicilliumchrysogenum
Létrehozó:
Varecza, Z.
Emri, T.
Pusztahelyi, TĂĽnde
PĂłcsi, I.
Kiadó:
Akadémiai Kiadó
Dátum:
2006
info:eu-repo/date/embargoEnd/2026-03-31
Téma:
QH Natural history / természetrajz
Tartalmi leírás:
NADPH is involved in many basically important anabolic processes. For a long time, pentose phosphate
pathway (PPS) was regarded as the most important source of NADPH in fungi. Here we present evidence
of a metabolic switch to an alternative NADPH-producing pathway in ageing
Penicillium chrysogenum
cultures, which involves NADP
+
-specific isocitrate dehydrogenase (NADP
+
-ID) rather than PPS
enzymes. Considering the main biochemical functions of NADPH, we propose that NADP
+
-ID could
have deep impact on many physiological processes switched on glucose deprivation including proteinase
production or penicillin biosynthesis. We also demonstrate that although the alternative pathway was
inferior to PPS when the fungus was grown on well-utilisable carbon sources yet it could have an impor-
tant role in fatty acid biosynthesis as well as in the maintenance of high intracellular NADPH/NADP
+
ratios.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Varecza, Z. and Emri, T. and Pusztahelyi, TĂĽnde and PĂłcsi, I. (2006) A novel aspect of NADPH production in ageing Penicilliumchrysogenum. Acta Biologica Hungarica, 57 (1). pp. 115-121. ISSN 0236-5383
Kapcsolat:
https://doi.org/10.1556/ABiol.57.2006.1.11
Létrehozó:
info:eu-repo/semantics/embargoedAccess