Differential distribution of NCX1 contributes to spine–dendrite compartmentalization in CA1 pyramidal cells
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Tartalom: http://real.mtak.hu/65066/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Differential distribution of NCX1 contributes to spine–dendrite compartmentalization in CA1 pyramidal cells
Létrehozó:
LĹ‘rincz, Andrea
Rózsa, Balázs
Katona, Gergely
Vizi, E. Sylvester
Tamás, Gábor
Kiadó:
National Academy of Sciences
Dátum:
2007-01-10
Téma:
QP Physiology / Ă©lettan
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Compartmentalization of Ca(2+) between dendritic spines and shafts is governed by diffusion barriers and a range of Ca(2+) extrusion mechanisms. The distinct contribution of different Ca(2+) clearance systems to Ca(2+) compartmentalization in dendritic spines versus shafts remains elusive. We applied a combination of ultrastructural and functional imaging methods to assess the subcellular distribution and role of NCX1 in rat CA1 pyramidal cells. Quantitative electron microscopic analysis of preembedding immunogold reactions revealed uniform densities of NCX1 along the shafts of apical and basal dendrites, but densities in dendritic shafts were approximately seven times higher than in dendritic spines. In line with these results, two-photon imaging of synaptically activated Ca(2+) transients during NCX blockade showed preferential action localized to the dendritic shafts for NCXs in regulating spine-dendrite coupling.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Lőrincz, Andrea and Rózsa, Balázs and Katona, Gergely and Vizi, E. Sylvester and Tamás, Gábor (2007) Differential distribution of NCX1 contributes to spine–dendrite compartmentalization in CA1 pyramidal cells. Proceedings of the National Academy of Sciences. pp. 1033-1038. ISSN 0027-8424
Kapcsolat:
https://doi.org/10.1073/pnas.0605412104