Altered activation of peripheral CD8+ T cells in pediatric Crohn's disease
  • Metaadatok
Tartalom: http://real.mtak.hu/64778/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Altered activation of peripheral CD8+ T cells in pediatric Crohn's disease
Létrehozó:
Orbán, Csaba
SzabĂł, DolĂłresz
Bajnok, Anna
Vásárhelyi, Barna
Tulassay, Tivadar
Arató, András
Veres, Gábor
Toldi, Gergely
Kiadó:
Elsevier; North-Holland
Dátum:
2017
Téma:
RJ Pediatrics / gyermekgyógyászat
Tartalmi leírás:
AIM: Although Crohn's disease (CD) is an extensively investigated autoimmune condition, knowledge on early phase activation of lymphocytes, especially CD8+ Tc cells is scarce. Our aim was to investigate the calcium influx characteristics of CD8+ cells upon activation as well as the expression and function of Kv1.3 and IKCa1 lymphocyte potassium channels. METHODS: We took peripheral blood from 12 healthy controls, 23 CD children on conventional therapy and 6 severe CD children before and after infliximab therapy. Intracellular calcium levels were monitored in CD8+ lymphocytes using flow cytometry. RESULTS: In CD treated with standard therapy calcium response during activation was elevated. This was not affected by the inhibition of Kv1.3 or IKCa1 potassium channels. After the switch to infliximab potassium channel function and expression of CD8+ lymphocytes were comparable to healthy controls in severe CD. CONCLUSION: Calcium handling of CD8+ lymphocytes is altered in pediatric CD, which is normalized by infliximab therapy.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Orbán, Csaba and Szabó, Dolóresz and Bajnok, Anna and Vásárhelyi, Barna and Tulassay, Tivadar and Arató, András and Veres, Gábor and Toldi, Gergely (2017) Altered activation of peripheral CD8+ T cells in pediatric Crohn's disease. IMMUNOLOGY LETTERS, 185. pp. 48-51. ISSN 0165-2478
Kapcsolat:
https://doi.org/10.1016/j.imlet.2017.03.009
MTMT:3207422; doi:10.1016/j.imlet.2017.03.009