NDA@SZTAKI

Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers

Sava, Florentina

Toldi, Gergely

Treszl, AndrĂĄs

HajdĂş, JĂşlia

Harmath, Ágnes

RigĂł, JĂĄnos

Tulassay, Tivadar

VĂĄsĂĄrhelyi, Barna

Wiley

2017

QR180 Immunology / immunolĂłgia

RG Gynecology and obstetrics / nőgyógyászat, szülészet

RJ Pediatrics / gyermekgyĂłgyĂĄszat

PROBLEM: To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers. METHOD OF STUDY: Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. RESULTS: The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. CONCLUSION: Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/64777/1/AJRI_2017_u.pdf

Sava, Florentina and Toldi, Gergely and Treszl, Andrås and Hajdú, Júlia and Harmath, Ágnes and Rigó, Jånos and Tulassay, Tivadar and Våsårhelyi, Barna (2017) Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 77 (6). pp. 1-9. ISSN 1046-7408

http://real.mtak.hu/64777/

https://doi.org/10.1111/aji.12659

MTMT:3208580; doi:10.1111/aji.12659