NDA@SZTAKI

The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia

Bajnok, Anna

Ivanova, M.

Rigó, János

Toldi, Gergely

2017

RG Gynecology and obstetrics / nőgyógyászat, szülészet

RJ Pediatrics / gyermekgyógyászat

INTRODUCTION: Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking. The characteristics of cellular adhesion molecules in preeclampsia are yet to be described. MATERIAL AND METHODS: Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins. RESULTS: We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy. No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes. CONCLUSIONS: Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/64776/1/Med_Inflamm_2017_PE_u.pdf

Bajnok, Anna and Ivanova, M. and Rigó, János and Toldi, Gergely (2017) The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia. MEDIATORS OF INFLAMMATION. No. 8045161. ISSN 0962-9351

http://real.mtak.hu/64776/

https://doi.org/10.1155/2017/8045161

MTMT:3235977; doi:10.1155/2017/8045161