Distance-Dependent Scaling of Calcium Transients Evoked by Backpropagating Spikes and Synaptic Activity in Dendrites of Hippocampal Interneurons
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Tartalom: http://real.mtak.hu/64233/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Distance-Dependent Scaling of Calcium Transients Evoked by Backpropagating Spikes and Synaptic Activity in Dendrites of Hippocampal Interneurons
Létrehozó:
Rozsa, Balázs
Zelles, Tibor
Vizi, Sylvester
Lendvai, Balazs
Kiadó:
Society for neuroscience
Dátum:
2004-01-21
Téma:
R1 Medicine (General) / orvostudomány általában
R850-854 Experimental medicine / kisérleti orvostudomány
Tartalmi leírás:
Although interactions between backpropagating action potentials and synaptic stimulations have been extensively studied in pyramidal
neurons, dendritic propagation and the summation of these signals in interneurons are not nearly as well known. In this study, twophoton
imaging was used to explore the basic properties of dendritic calcium signaling in CA1 stratum radiatum interneurons. In
contrast to hippocampal pyramidal neurons, the backpropagating action potential-evoked calcium transients in dendrites of interneurons
underwent a distance-dependent increment. Although, in proximal dendrites, an increment could be attributed to a smaller dendrite
diameter, distal dendrites did not show such dependence. Calcium responses in interneurons had a smaller amplitude, slower rise time,
and decay than in pyramidal neurons. To explore the factors underlying the difference, we compared the calcium-binding capacity in
interneurons and in pyramidal neurons. Our finding that endogenous calcium buffers had a higher level in interneurons may primarily
explain the different kinetics and amplitudes of calcium transients. Synaptic stimulation-evoked calcium transients were also larger at
distant dendritic locations. The spread of these signals was restricted to 12–13 m long dendritic compartments. Supporting the reported
lack of long-term potentiation in these interneurons, we found only sublinear or linear summations of calcium responses to coincident
synaptic inputs and backpropagating spikes.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Rozsa, Balázs and Zelles, Tibor and Vizi, Sylvester and Lendvai, Balazs (2004) Distance-Dependent Scaling of Calcium Transients Evoked by Backpropagating Spikes and Synaptic Activity in Dendrites of Hippocampal Interneurons. The Journal of Neuroscience, 24 (3). pp. 661-670. ISSN 1529-2401
Kapcsolat:
https://doi.org/10.1523/JNEUROSCI.3906-03.2004