Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves

Metaadatok

Tartalom:	http://real.mtak.hu/64221/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves
Létrehozó:	Chiovini, BalÃ¡zs Turi, Gergely F. Katona, Gergely KaszÃ¡s, Attila PÃ¡lfi, DÃ©nes MaÃ¡k, PÃ¡l Szalay, Gergely SzabÃ³, MÃ¡tyÃ¡s ForiÃ¡n SzabÃ³, GÃ¡bor Szadai, ZoltÃ¡n KÃ¡li, Szabolcs RÃ³zsa, BalÃ¡zs
Kiadó:	Elsevier
Dátum:	2014-05-21
Téma:	R1 Medicine (General) / orvostudomÃ¡ny Ã¡ltalÃ¡ban R850-854 Experimental medicine / kisÃ©rleti orvostudomÃ¡ny
Tartalmi leírás:	Sharp-wave ripples are transient oscillatory events in the hippocampus that are associated with the reactivation of neuronal ensembles within specific circuits during memory formation. Fast-spiking, parvalbumin-expressing interneurons (FS-PV INs) are thought to provide fast integration in these oscillatory circuits by suppressing regenerative activity in their dendrites. Here, using fast 3D two-photon imaging and a caged glutamate, we challenge this classical view by demonstrating that FS-PV IN dendrites can generate propagating Ca2+ spikes during sharp-wave ripples. The spikes originate from dendritic hot spots and are mediated dominantly by L-type Ca2+ channels. Notably, Ca2+ spikes were associated with intrinsically generated membrane potential oscillations. These oscillations required the activation of voltage-gated Na+ channels, had the same frequency as the field potential oscillations associated with sharp-wave ripples, and controlled the phase of action potentials. Furthermore, our results demonstrate that the smallest functional unit that can generate ripple-frequency oscillations is a segment of a dendrite.
Nyelv:	magyar
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text
Azonosító:	http://real.mtak.hu/64221/1/Rozsa_Dendritic%20Spikes%20Indu... Chiovini, BalÃ¡zs and Turi, Gergely F. and Katona, Gergely and KaszÃ¡s, Attila and PÃ¡lfi, DÃ©nes and MaÃ¡k, PÃ¡l and Szalay, Gergely and SzabÃ³, MÃ¡tyÃ¡s ForiÃ¡n and SzabÃ³, GÃ¡bor and Szadai, ZoltÃ¡n and KÃ¡li, Szabolcs and RÃ³zsa, BalÃ¡zs (2014) Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves. NEURON, 82 (4). pp. 908-924. ISSN 0896-6273
Kapcsolat:	http://real.mtak.hu/64221/ http://doi.org/10.1016/j.neuron.2014.04.004 doi:10.1016/j.neuron.2014.04.004