Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex
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Tartalom: http://real.mtak.hu/64212/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex
Létrehozó:
Hillier, Daniel
Fiscella, Michele
Drinnenberg, Antonia
Trenholm, Stuart
Rompani, Santiago B
Raics, Zoltan
Katona, Gergely
Juettner, Josephine
Hierlemann, Andreas
Rozsa, Balazs
Roska, Botond
Kiadó:
Nature Publishing Group
Dátum:
2017-05-22
Téma:
R1 Medicine (General) / orvostudomány általában
R850-854 Experimental medicine / kisérleti orvostudomány
Tartalmi leírás:
How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined
this question in the context of visual-motion processing in the retina and primary visual cortex (V1) of mice. We disrupted retinal
direction selectivity, either exclusively along the horizontal axis using FRMD7 mutants or along all directions by ablating starburst
amacrine cells, and monitored neuronal activity in layer 2/3 of V1 during stimulation with visual motion. In control mice, we found
an over-representation of cortical cells preferring posterior visual motion, the dominant motion direction an animal experiences
when it moves forward. In mice with disrupted retinal direction selectivity, the over-representation of posterior-motion-preferring
cortical cells disappeared, and their responses at higher stimulus speeds were reduced. This work reveals the existence of two
functionally distinct, sensory-periphery-dependent and -independent computations of visual motion in the cortex.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Hillier, Daniel and Fiscella, Michele and Drinnenberg, Antonia and Trenholm, Stuart and Rompani, Santiago B and Raics, Zoltan and Katona, Gergely and Juettner, Josephine and Hierlemann, Andreas and Rozsa, Balazs and Roska, Botond (2017) Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex. Nature Neuroscience, 20 (7). pp. 960-968. ISSN 1097-6256
Kapcsolat:
doi:10.1038/nn.4566