Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons
  • Metaadatok
Tartalom: http://real.mtak.hu/64207/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published
Type = Article
Cím:
Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons
Létrehozó:
Du, Kai
Wu, Yu-Wei
Lindroos, Robert
Liu, Yu
Rózsa, Balázs
Katona, Gergely
Ding, Jun B.
Kotaleski, Jeanette Hellgren
Kiadó:
NATL ACAD PRESS
Dátum:
2017-08-21
Téma:
R850-854 Experimental medicine / kisérleti orvostudomány
Tartalmi leírás:
Striatal spiny projection neurons (SPNs) receive convergent excitatory
synaptic inputs from the cortex and thalamus. Activation of spatially
clustered and temporally synchronized excitatory inputs at the distal
dendrites could trigger plateau potentials in SPNs. Such supralinear
synaptic integration is crucial for dendritic computation. However,
how plateau potentials interact with subsequent excitatory and
inhibitory synaptic inputs remains unknown. By combining computational
simulation, two-photon imaging, optogenetics, and dualcolor
uncaging of glutamate and GABA, we demonstrate that plateau
potentials can broaden the spatiotemporal window for integrating
excitatory inputs and promote spiking. The temporal window of
spiking can be delicately controlled by GABAergic inhibition in a celltype–specific
manner. This subtle inhibitory control of plateau potential
depends on the location and kinetics of the GABAergic inputs and
is achieved by the balance between relief and reestablishment of
NMDA receptor Mg2+ block. These findings represent a mechanism
for controlling spatiotemporal synaptic integration in SPNs.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Du, Kai and Wu, Yu-Wei and Lindroos, Robert and Liu, Yu and Rózsa, Balázs and Katona, Gergely and Ding, Jun B. and Kotaleski, Jeanette Hellgren (2017) Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114 (36). E7612-E7621. ISSN 0027-8424
Kapcsolat:
https://doi.org/10.1073/pnas.1704893114
doi: 10.1073/pnas.1704893114