Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments
  • Metaadatok
Tartalom: http://real.mtak.hu/63771/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments
Létrehozó:
Chandrakumar, Lalitha
Bagyánszki, Mária
Szalai, Zita
Mezei, Diána
BĂłdi, Nikolett
Kiadó:
Hindawi Publishing Corporation
Dátum:
2017-09-10
Téma:
RC Internal medicine / belgyógyászat
RC658.5 Diabetes / diabetolĂłgia
Tartalmi leírás:
Increase in hyperglycaemia-induced oxidative stress and decreased effectiveness of endogenous defense mechanisms plays an
essential role in the initiation of diabetes-related neuropathy. We demonstrated that nitrergic myenteric neurons display
different susceptibilities to diabetic damage in different gut segments. Therefore, we aim to reveal the gut segment-specific
differences in the expression of heme oxygenase (HO) isoforms and the colocalization of these antioxidants with neuronal nitric
oxide synthase (nNOS) in myenteric neurons. After ten weeks, samples from the duodenum, ileum, and colon of control and
streptozotocin-induced diabetic rats were processed for double-labelling fluorescent immunohistochemistry and ELISA. The
number of both HO-immunoreactive and nNOS/HO-immunoreactive myenteric neurons was the lowest in the ileal and the
highest in the colonic ganglia of controls; it increased the most extensively in the ileum and was also elevated in the colon of
diabetics. Although the total number of nitrergic neurons decreased in all segments, the proportion of nNOS-immunoreactive
neurons colocalizing with HOs was enhanced robustly in the ileum and colon of diabetics. We presume that those nitrergic
neurons which do not colocalize with HOs are the most seriously affected by diabetic damage. Therefore, the regional induction
of the HO system is strongly correlated with diabetes-related region-specific nitrergic neuropathy.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Chandrakumar, Lalitha and Bagyánszki, Mária and Szalai, Zita and Mezei, Diána and Bódi, Nikolett (2017) Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments. Oxidative Medicine and Cellular Longevity. pp. 1-14. ISSN 1942-0994
Kapcsolat:
https://doi.org/10.1155/2017/1890512
Article ID 1890512