Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency
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Tartalom: http://real.mtak.hu/63614/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency
Létrehozó:
Czaller, Ibolya
Csuka, Dorottya
Zotter, Zsuzsanna
Veszeli, NĂłra
Takács, Edit
Varga, Lilian
Farkas, Henriette
Kiadó:
Elsevier
Dátum:
2016
Téma:
RC Internal medicine / belgyógyászat
Tartalmi leírás:
BACKGROUND: Thyroid hormones control and up-regulate the synthesis of many plasma proteins. OBJECTIVE: To explore possible associations between thyroid hormone and complement levels in patients with hereditary angioedema resulting from the deficiency of the C1-inhibitor (C1-INH-HAE). METHODS: In this case-control study, serum thyrotropin, free triiodothyronine (FT3), and free thyroxine (FT4) levels, anti-thyroid peroxidase and antithyroglobulin antibody titers, and C1-INH concentrations were measured in 117 euthyroid patients with C1-INH-HAE and compared with their clinical properties. The control group comprised 150 healthy, age- and sex-matched, euthyroid individuals. RESULTS: The thyrotropin and antithyroglobulin levels were similar between the patients and the controls. Significantly lower FT3 (P < .001) and FT4 (P = .002) levels, as well as higher anti-thyroid peroxidase titers (P < .001), were seen in the patients with C1-INH-HAE. The proportion of patients with reduced C1-INH activity was greater among those with below-median FT4 levels than among those with above-median values (P = .02). Patients who experienced more edematous attacks per year had lower FT4 levels (within the normal range) than those afflicted by fewer episodes (P = .01). The FT3 and FT4 levels were significantly higher in patients undergoing long-term danazol therapy than in those who did not receive this drug (P = .01 and P = .02, respectively). The proportion of patients with FT4 levels in the below-median range was higher in the subset with increased d-dimer concentration (P = .009). CONCLUSION: Minor variations of the thyroid hormone levels (within the reference range) can influence the function of C1-INH in C1-INH-HAE. Our findings suggest a role for the endocrine system in the pathophysiology of C1-INH-HAE.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Czaller, Ibolya and Csuka, Dorottya and Zotter, Zsuzsanna and Veszeli, Nóra and Takács, Edit and Varga, Lilian and Farkas, Henriette (2016) Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 117 (2). pp. 175-179. ISSN 1081-1206
Kapcsolat:
https://doi.org/10.1016/J.ANAI.2016.06.005
MTMT:3104474; doi:10.1016/j.anai.2016.06.005