The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms

Metaadatok

Tartalom:	http://real.mtak.hu/63251/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms
Létrehozó:	KovÃ¡cs, Tibor Billes, Viktor AndrÃ¡s KomlÃ³s, Marcell Hotzi, Bernadette ManzÃ©ger, Anna RÃ¡cz, Ãkos NoszÃ¡l, BÃ©la Veszelka, Szilvia Walter, Fruzsina Deli, MÃ¡ria Anna AlfÃ¶ldi, RÃ³bert PuskÃ¡s, LÃ¡szlÃ³ Liliom, Hanna Laura TÃ¡rnok, KrisztiÃ¡n Schlett, Katalin Borsy, Adrienn Ã‰va Welker, Ervin PÃ¡dÃ¡r, Zsolt LÃ©grÃ¡di, ÃdÃ¡m Bjelik, AnnamÃ¡ria Gulya, KÃ¡roly Vellai, Tibor
Kiadó:	Nature Publishing Group
Dátum:	2017
Téma:	QH3011 Biochemistry / biokÃ©mia QH3015 Molecular biology / molekulÃ¡ris biolÃ³gia
Tartalmi leírás:	Autophagy functions as a main route for the degradation of superfluous and damaged constituents of the cytoplasm. Defects in autophagy are implicated in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration and tissue atrophy, and in accelerated aging. To promote basal levels of the process in pathological settings, we previously screened a small molecule library for novel autophagy-enhancing factors that inhibit the myotubularin-related phosphatase MTMR14/Jumpy, a negative regulator of autophagic membrane formation. Here we identify AUTEN-99 (autophagy enhancer-99), which activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson's and Huntington's diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.
Nyelv:	angol
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text
Azonosító:	http://real.mtak.hu/63251/1/KovacsSciRep.pdf KovÃ¡cs, Tibor and Billes, Viktor AndrÃ¡s and KomlÃ³s, Marcell and Hotzi, Bernadette and ManzÃ©ger, Anna and RÃ¡cz, Ãkos and NoszÃ¡l, BÃ©la and Veszelka, Szilvia and Walter, Fruzsina and Deli, MÃ¡ria Anna and AlfÃ¶ldi, RÃ³bert and PuskÃ¡s, LÃ¡szlÃ³ and Liliom, Hanna Laura and TÃ¡rnok, KrisztiÃ¡n and Schlett, Katalin and Borsy, Adrienn Ã‰va and Welker, Ervin and PÃ¡dÃ¡r, Zsolt and LÃ©grÃ¡di, ÃdÃ¡m and Bjelik, AnnamÃ¡ria and Gulya, KÃ¡roly and Vellai, Tibor (2017) The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. SCIENTIFIC REPORTS, 7. pp. 1-17. ISSN 2045-2322
Kapcsolat:	http://real.mtak.hu/63251/ https://doi.org/10.1038/srep42014 MTMT:3190920; doi:10.1038/srep42014