| Tartalom: |
http://real.mtak.hu/62260/ |
| Archvum: |
MTA Knyvtr |
| Gyjtemny: |
Status = Published
Type = Article
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| Cm: |
A 30 KB region of the Epstein-Barr virus genome is colinear with the rearranged human immunoglobulin gene loci: Implications for a “Ping-Pong Evolution” model for persisting viruses and their hosts
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| Ltrehoz: |
Niller, H. H.
Salamon, D.
Rahmann, S.
Ilg, Karin
Koroknai, Anita
Bánáti, F.
Schwarzmann, F.
Wolf, H.
Minárovits, J.
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| Kiad: |
Akadémiai Kiadó
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| Dtum: |
2004
info:eu-repo/date/embargoEnd/2024-12-31
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| Tma: |
QR Microbiology / mikrobiológia
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| Tartalmi lers: |
The left part of the Epstein-Barr virus (EBV) genome exhibits a strong colinearity of structural and functional elements with the immunoglobulin (Ig) gene loci which is only partially reflected in nucleotide sequence homologies. We propose that this colinearity may be the result of an inter-dependent co-evolution of the immunoglobulin loci together with EBV. Our observation could help elucidating the mechanisms of somatic hypermutation, explaining the ability of EBV to accidentally cause tumors, and shedding more light on the general mechanisms of viral and organismal evolution. We suggest that persisting viruses served as a complement for the organismal germline like in a ping-pong game and outline The Ping-Pong Evolution Hypothesis.
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| Nyelv: |
magyar
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| Tpus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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| Formtum: |
text
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| Azonost: |
Niller, H. H. and Salamon, D. and Rahmann, S. and Ilg, Karin and Koroknai, Anita and Bánáti, F. and Schwarzmann, F. and Wolf, H. and Minárovits, J. (2004) A 30 KB region of the Epstein-Barr virus genome is colinear with the rearranged human immunoglobulin gene loci: Implications for a “Ping-Pong Evolution” model for persisting viruses and their hosts. Acta Microbiologica et Immunologica Hungarica, 51 (4). pp. 469-484. ISSN 1217-8950
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| Kapcsolat: |
https://doi.org/10.1556/AMicr.51.2004.4.7
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| Ltrehoz: |
info:eu-repo/semantics/embargoedAccess
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