Triflupromazine: a microbicide non-antibiotic compound
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Tartalom: http://real.mtak.hu/62238/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Triflupromazine: a microbicide non-antibiotic compound
Létrehozó:
Dastidar, Sujata G.
Debnath, Sanchayita
Mazumdar, Kaushiki
Ganguly, Kumkum
Chakrabarty, A. N.
Kiadó:
Akadémiai Kiadó
Dátum:
2004
info:eu-repo/date/embargoEnd/2024-05-31
Téma:
QR Microbiology / mikrobiolĂłgia
Tartalmi leírás:
The antipsychotic phenothiazine triflupromazine, possessing a methyl-thio substituent at position 10 and a fluorine moiety at position 2, exhibited significant antibacterial activity against 279 strains of Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration (MIC) of the drug, according to the agar dilution method, was between 2 and 50 µg/ml for Staphylococcus aureus, and 5 and 100 µg/ml for shigellae and vibrios. Triflupromazine, when injected intraperitoneally into Swiss albino mice at a concentration of 30 µg/mouse (20 g), manifested a significant protection to the mice (p<0.001) when they were challenged with 50 median lethal dose (MLD) of Salmonella typhimurium NCTC 74. Moreover, there was a statistically significant reduction in the number of viable bacteria in organ homogenates and blood of mice treated with this phenothiazine compound.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Dastidar, Sujata G. and Debnath, Sanchayita and Mazumdar, Kaushiki and Ganguly, Kumkum and Chakrabarty, A. N. (2004) Triflupromazine: a microbicide non-antibiotic compound. Acta Microbiologica et Immunologica Hungarica, 51 (1-2). pp. 75-83. ISSN 1217-8950
Kapcsolat:
https://doi.org/10.1556/AMicr.51.2004.1-2.5
Létrehozó:
info:eu-repo/semantics/embargoedAccess