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Kapcsolat
Vertical transmission of human immunodeficiency virus (A review) |
Tartalom: | http://real.mtak.hu/62125/ |
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Archívum: | MTA Könyvtár |
Gyűjtemény: |
Status = Published
Type = Article |
Cím: |
Vertical transmission of human immunodeficiency virus (A review)
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Létrehozó: |
TĂłth, Ferenc D.
Bácsi, Attila
Beck, Zoltán
SzabĂł, Judit
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Kiadó: |
Akadémiai Kiadó
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Dátum: |
2001
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Téma: |
QR Microbiology / mikrobiolĂłgia
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Tartalmi leírás: |
Sensitive detection methods, such as DNA PCR and RNA PCR suggest that vertical transmission of human immunodeficiency virus (HIV) occurs at three major time periods; in utero, around the time of birth, and postpartum as a result of breastfeeding (Fig. 1). Detection of proviral DNA in infant's blood at birth suggests that transmission occurred prior to delivery. A working definition for time of infection is that HIV detection by DNA PCR in the first 48 h of life indicates in utero transmission, while peripartum transmission is considered if DNA PCR is negative the first 48 h, but then it is positive 7 or more days later [1]. Generally, in the breastfeeding population, breast milk transmission is thought to occur if virus is not detected by PCR at 3–5 months of life but is detected thereafter within the breastfeeding period [2]. Using these definitions and guidelines, studies has suggested that in developed countries the majority, or two thirds of vertical transmission occur peripartum, and one-third in utero [3–6]. The low rate of breastfeeding transmission is due to the practice of advising known HIV-positive mothers not to feed breast milk. However, since the implementation of antiretroviral treatment in prophylaxis of HIV-positive mothers, some studies have suggested that in utero infection accounts for a larger percentage of vertical transmissions [7]. In developing countries, although the majority of infections occurs also peripartum, a significant percentage, 10–17%, is thought to be due to breastfeeding [2, 8, 9].
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Nyelv: |
magyar
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Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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Formátum: |
text
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Azonosító: |
Tóth, Ferenc D. and Bácsi, Attila and Beck, Zoltán and Szabó, Judit (2001) Vertical transmission of human immunodeficiency virus (A review). Acta Microbiologica et Immunologica Hungarica, 48 (3-4). pp. 413-427. ISSN 1217-8950
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Kapcsolat: |
https://doi.org/10.1556/AMicr.48.2001.3-4.10
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