Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
  • Metaadatok
Tartalom: http://real.mtak.hu/61645/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published



Type = Article
Cím:
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
Létrehozó:
Radák, Zsolt
Zhao, Z.
Goto, Sataro
Koltai, Erika
Kiadó:
Pergamon Press
Dátum:
2011
Téma:
QH3011 Biochemistry / biokémia
QH3015 Molecular biology / molekuláris biológia
R1 Medicine (General) / orvostudomány általában
Tartalmi leírás:
Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in the last quarter of the life span. The so called base level of oxidative modification of lipids could be important to cell signaling, and membrane remodeling, but the ROS-mediated post translation modifications of proteins could be important to the homeostasis of protein turnover. Low levels of 8-oxo-7,8-dihydroguanine (8-oxoG) might be necessary for transcription. A high level of accumulation of lipid peroxidation, oxidative protein damage or 8-oxoG, on the other hand, accelerates the progress of aging and neurodegenerative diseases. Therefore, agents that induce the activity of repair enzymes, such as Ca(2(+))-independent phospholipase A(2) (iPLA(2)beta), methionine sulfoxide reductase, and 8-oxoguanine DNA glycosylase, or the activity of enzymes that could prevent the accumulation of oxidized, toxic proteins, such as proteasome, Lon protease, neprilysin or insulin degrading enzyme, may act as potential therapeutic tools to slow the aging process and the progress of neurodegenerative diseases.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Radák, Zsolt and Zhao, Z. and Goto, Sataro and Koltai, Erika (2011) Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. MOLECULAR ASPECTS OF MEDICINE, 32 (4-6). pp. 305-315. ISSN 0098-2997
Kapcsolat:
https://doi.org/10.1016/j.mam.2011.10.010
MTMT:1769020; doi:10.1016/j.mam.2011.10.010