NDA@SZTAKI

Genetic Diversity and Zoonotic Potential of Human Rotavirus Strains, 2003–2006, Hungary

BĂĄnyai, KrisztiĂĄn

Bogdån, Ágnes

Domonkos, Gertrud

Kisfali, PĂŠter

MolnĂĄr, PĂŠter

TĂłth, AndrĂĄs

Melegh, BĂŠla

Vito, Martella

Gentsch, Jon R

SzĹącs, GyĂśrgy

Wiley

2008-12-23

QR355 Virology / vĂ­ruskutatĂĄs

Rotavirus strain surveillance is being conducted
in many countries before and after introduction
of newly licensed vaccines to assess the impact
of the vaccines on rotavirus strains. Here we
describe a strain surveillance study in the Buda-
pest area of Hungary (2003–2006) based on RNA
profile analysis, genotyping by multiplex PCR and
nucleotide sequencing. Among 1,983 G-typed
rotaviruses we identified G1 (22%), G2 (4.8%), G3
(3.5%), G4 (18.5%), G6 (1.1%), G8 (<0.1%, n Âź 1),
G9 (42%), and G12 (3.4%) specificities. Informa-
tion on P genotype incidence was determined for
a subset of samples (n Âź 814). In addition to the
globally important strains, a variety of uncom-
mon antigen combinations were also found,
for example, P[9],G3; P[14],G6; or P[14],G8.
Sequence and phylogenetic analysis of the VP7,
VP4, VP6, and NSP4 genes of selected strains with
uncommon antigen combinations demonstrated
high similarity with certain bovine, porcine,
feline, equine, and lapine rotaviruses, respec-
tively. Continued surveillance is needed to assess
the role of animal rotaviruses in human diseases.

magyar

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/58920/1/B-nyai_et_al-2009-Journal_of_Me...

Bányai, Krisztián and Bogdán, Ágnes and Domonkos, Gertrud and Kisfali, Péter and Molnár, Péter and Tóth, András and Melegh, Béla and Vito, Martella and Gentsch, Jon R and Szűcs, György (2008) Genetic Diversity and Zoonotic Potential of Human Rotavirus Strains, 2003–2006, Hungary. JOURNAL OF MEDICAL VIROLOGY, 81 (2). pp. 362-370. ISSN 0146-6615

http://real.mtak.hu/58920/

https://doi.org/10.1002/jmv.21375