| Tartalom: |
http://real.mtak.hu/55850/ |
| Archívum: |
MTA Könyvtár |
| Gyűjtemény: |
Status = Published
Type = Article
|
| Cím: |
Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels–Alder Reactions
|
| Létrehozó: |
Kozma, E.
Demeter, Orsolya
Kele, PĂ©ter
|
| Kiadó: |
Wiley-VCH Verlag GmbH & Co. KGaA
|
| Dátum: |
2017
|
| Téma: |
QD04 Organic chemistry / szerves kémia
QH301 Biology / biolĂłgia
|
| Tartalmi leírás: |
Bio-ort
hogona
llabellin
gschemes
based
on inverse-elec
tron-
deman
dDiels–Ald
er (IEDDA)
cycloa
ddition
have
attracted
much
attention
in chem
ical biology
recently
.The appeal
ing
features
of this reactio
n, such
as the fast reactio
nkinetics,
fully
bio-ort
hogonal
nature
and high
selectiv
ity,have helped
chem
i-
cal biologists
gain
deeper
understandi
ng of biochemic
al pro-
cesses
at the molecular
level.Listing
the compo
nents
and dis-
cussing
the possib
ilities
andlimitations
of thesereagent
s, we
provid
earecent
snapshot
of the field
of IEDDA
-based
biomo-
lecular
manipulatio
nwith special
focus
on fluores
cent
modula-
tion
approaches
throug
hthe use of bio-orthogon
alized
build-
ing blocks.
At the end,
we discuss
challenges
that
need
to be
addres
sed
for further
develop
ments
in order
to overcome
recent
limita
tions
and to enabl
eresearchers
to answer
biomo
-
lecular
quest
ions in more
detail.
|
| Nyelv: |
angol
|
| Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
|
| Formátum: |
text
|
| Azonosító: |
Kozma, E. and Demeter, Orsolya and Kele, Péter (2017) Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels–Alder Reactions. CHEMBIOCHEM, 18. pp. 486-501. ISSN 1439-4227
|
| Kapcsolat: |
https://doi.org/10.1002/cbic.201600607
MTMT:3177637; doi:10.1002/cbic.201600607
|
