ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia

Metaadatok

Tartalom:	http://real.mtak.hu/54827/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia
Létrehozó:	Semsei, Ãgnes F ErdÃ©lyi, DÃ¡niel UngvÃ¡ri, IldikÃ³ Csagoly, Edit Hegyi, MÃ¡rta Lautner-Csorba, Orsolya Szabolcs, Judit Fekete, GyÃ¶rgy Falus, AndrÃ¡s Szalai, Csaba KovÃ¡cs, GÃ¡bor
Kiadó:	Wiley
Dátum:	2012
Téma:	RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolÃ³gia
Tartalmi leírás:	Anthracyclines are potent cytostatic drugs the correct dosage of which is critical to aviod possible cardiac side effects. ABCC1 (MRP1) is expressed in the heart and takes part in the detoxification and protection of the cells from toxic effects of xenobiotics, including anthracyclines. Our objective was to search for associations between left ventricular function and single nucleotide polymorphisms of the ABCC1 gene in children who received anthracycline chemotherapy. We analyzed data of 235 pediatric patients with acute lymphoblastic leukemia. Patients were followed up by echocardiography (median follow up 6.3 years). Nine polymorphisms in the ABCC1 gene were genotyped. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were found to be associated with lower left ventricular fractional shortening (LVFS) after chemotherapy. Our results suggest that genetic variants in the ABCC1 gene could influence anthracycline induced left ventricular dysfunction.
Nyelv:	magyar angol
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text text
Azonosító:	http://real.mtak.hu/54827/7/ANT_cikk_cbi20110264-1.pdf http://real.mtak.hu/54827/1/CBI20110264.pdf Semsei, Ãgnes F and ErdÃ©lyi, DÃ¡niel and UngvÃ¡ri, IldikÃ³ and Csagoly, Edit and Hegyi, MÃ¡rta and Lautner-Csorba, Orsolya and Szabolcs, Judit and Fekete, GyÃ¶rgy and Falus, AndrÃ¡s and Szalai, Csaba and KovÃ¡cs, GÃ¡bor (2012) ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. CELL BIOLOGY INTERNATIONAL, 36 (1). pp. 79-86. ISSN 1065-6995
Kapcsolat:	http://real.mtak.hu/54827/ https://doi.org/10.1042/CBI20110264 MTMT:1769902; doi:10.1042/CBI20110264