The Correlation of Ultrasonographic and Pathophysiologic Measurements of Umbilical Vessels in Gestational Diabetes 1
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Tartalom: http://real.mtak.hu/53468/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
The Correlation of Ultrasonographic and Pathophysiologic Measurements of Umbilical Vessels in Gestational Diabetes 1
Létrehozó:
Jakó, Mária
Surányi, Andrea
Kaizer, László
Domokos, DĂłra
Bártfai, György
Dátum:
2017
Téma:
RC658.5 Diabetes / diabetolĂłgia
RG Gynecology and obstetrics / nőgyógyászat, szülészet
Tartalmi leírás:
Aim: The resistance of placental blood vessels might be
increased in diabetic pregnancies. This
increased resistance can affect uteroplacental blood flow and
influence the oxygen and nutrient
supply of the fetus and fetal growth. Our aim was to compare the
ultrasonographic,
pathomorphologic data and vasoreactivity of umbilical and
placental vessels of gestational diabetic
newborns with that of normal pregnancy newborns.
Methods: In this case-control study the placental
vascularization of pregnant women was
determined by 3D power Doppler ultrasound technique. We
calculated the vascularization index (VI),
flow index (FI) and vascularization flow index (VFI). We
performed a tissue bath experiment (treatment
with oxytocin and desmopressin) on umbilical vessels and
collected pathomorphologic data
according to the Royal College of Pathologists’ 2011 protocol.
Results: The placental vascularization index and the umbilical
artery S/D were significantly lower in
the case group. The mean VI was 6.21% (±2.69 SD) in control
versus 3.5% (±2.97 SD) (p<0.05) in GDM.
The mean value of the umbilical artery S/D was 2.27 (±0.22 SD)
and 2.18 (±0.45 SD) (p<0.05)
respectively. In an isolated tissue bath experiment, oxytocin
and desmopressin did not elicit
significant contraction on umbilical cord vessels.
Conclusion: Our results suggest that umbilical vessels might
have a different receptor pathway
regulation that can compensate for the rheological changes in
the pregnant woman’s blood flow and
gives opportunity for selective therapy to fetuses more
vulnerable to hypoxia.
(Jakó M, Surányi A, Kaizer L, Domokos D, Bártfai G. The
Correlation of Ultrasonographic and
Pathophysiologic Measurements of Umbilical Vessels in
Gestational Diabetes. SEEMEDJ 2017;1(1);40-
49)
Nyelv:
angol
Típus:
Article
NonPeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Jakó, Mária and Surányi, Andrea and Kaizer, László and Domokos, Dóra and Bártfai, György (2017) The Correlation of Ultrasonographic and Pathophysiologic Measurements of Umbilical Vessels in Gestational Diabetes 1. Southeastern European Medical Journal, 1 (1). pp. 40-49. ISSN 2459-9484
Kapcsolat:
MTMT:3223543