Thalamic Inhibition: Diverse Sources, Diverse Scales.
  • Metaadatok
Tartalom: http://real.mtak.hu/52199/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Thalamic Inhibition: Diverse Sources, Diverse Scales.
Létrehozó:
Halassa, Michael M.
Acsády, László
Kiadó:
Elsevier
Dátum:
2016
Téma:
R1 Medicine (General) / orvostudomány általában
R850-854 Experimental medicine / kisérleti orvostudomány
Tartalmi leírás:
The thalamus is the major source of cortical inputs shaping sensation, action, and cognition. Thalamic circuits are targeted by two major inhibitory systems: the thalamic reticular nucleus (TRN) and extrathalamic inhibitory (ETI) inputs. A unifying framework of how these systems operate is currently lacking. Here, we propose that TRN circuits are specialized to exert thalamic control at different spatiotemporal scales. Local inhibition of thalamic spike rates prevails during attentional selection, whereas global inhibition more likely prevails during sleep. In contrast, the ETI (arising from basal ganglia, zona incerta (ZI), anterior pretectum, and pontine reticular formation) provides temporally precise and focal inhibition, impacting spike timing. Together, these inhibitory systems allow graded control of thalamic output, enabling thalamocortical operations to dynamically match ongoing behavioral demands.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Halassa, Michael M. and Acsády, László (2016) Thalamic Inhibition: Diverse Sources, Diverse Scales. Trends in Neurosciences, 39 (10). pp. 680-693. ISSN 0166-2236
Kapcsolat:
https://doi.org/10.1016/j.tins.2016.08.001
MTMT:3206618; doi:10.1016/j.tins.2016.08.001