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Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats.

Fodor, Anna

Kovács, Krisztina Bea

Balázsfi, Diána

Klausz, Barbara

Pintér, Ottó

Demeter, Kornél

Zelena, DĂłra

Elsevier

2016

QP Physiology / Ă©lettan

R1 Medicine (General) / orvostudomány általában

R850-854 Experimental medicine / kisérleti orvostudomány

Vasopressin can contribute to the development of stress-related psychiatric disorders, anxiety and depression. Although these disturbances are more common in females, most of the preclinical studies have been done in males. We compared female vasopressin-deficient and +/+ Brattleboro rats. To test anxiety we used open-field, elevated plus maze (EPM), marble burying, novelty-induced hypophagia, and social avoidance tests. Object and social recognition were used to assess short term memory. To test depression-like behavior consumption of sweet solutions (sucrose and saccharin) and forced swim test (FST) were studied. The stress-hormone levels were followed by radioimmunoassay and underlying brain areas were studied by c-Fos immunohistochemistry. In the EPM the vasopressin-deficient females showed more entries towards the open arms and less stretch attend posture, drank more sweet fluids and struggled more (in FST) than the +/+ rats. The EPM-induced stress-hormone elevations were smaller in vasopressin-deficient females without basal as well as open-field and FST-induced genotype-differences. On most studied brain areas the resting c-Fos levels were higher in vasopressin-deficient rats, but the FST-induced elevations were smaller than in the +/+ ones. Similarly to males, female vasopressin-deficient animals presented diminished depression- and partly anxiety-like behavior with significant contribution of stress-hormones. In contrast to males, vasopressin deficiency in females had no effect on object and social memory, and stressor-induced c-Fos elevations were diminished only in females. Thus, vasopressin has similar effect on anxiety- and depression-like behavior in males and females, while only in females behavioral alterations are associated with reduced neuronal reactivity in several brain areas.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/52198/1/Balazsfi_Dia_u.pdf

Fodor, Anna and Kovács, Krisztina Bea and Balázsfi, Diána and Klausz, Barbara and Pintér, Ottó and Demeter, Kornél and Zelena, Dóra (2016) Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats. Physiology and Behavior, 158. pp. 100-111. ISSN 0031-9384

http://real.mtak.hu/52198/

https://doi.org/10.1016/j.physbeh.2016.02.041

MTMT:3036732; doi:10.1016/j.physbeh.2016.02.041