The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects
  • Metaadatok
Tartalom: http://real.mtak.hu/52124/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects
Létrehozó:
Viski, Sándor Zsolt
Orosz, MiklĂłs
Czuriga-Kovács, Katalin Réka
Magyar, Mária Tünde
Csiba, László
Oláh, László
Kiadó:
Elsevier
Dátum:
2016
Téma:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
RJ Pediatrics / gyermekgyógyászat
Tartalmi leírás:
BACKGROUND: Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects. METHODS: Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake. RESULTS: The HUT test resulted in a more prominent decline of adjusted mBP at the level of MCAs (mBPMCA) and a significantly larger decrease of MCA mean flow velocities (MFVMCA) in the post-alcohol period than before alcohol intake. During the HUT phase, the relative decrease in MFVMCA was significantly smaller than the reduction in mBPMCA before drinking alcohol, while these changes were similar after alcohol ingestion. The cerebrovascular resistance index (CVRi) decreased during the HUT phase in the control period, however, it increased after alcohol intake. CONCLUSION: The similar decrease in mBPMCA and MFVMCA during orthostatic stress after alcohol ingestion together with the increased CVRi indicated the impairment of the compensatory vasodilation of cerebral resistance vessels, i.e. impaired cerebral autoregulation. These findings suggest that alcohol may contribute to impaired orthostatic tolerance not only by a hypotensive response but also by the alteration of cerebral blood flow regulation.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Viski, Sándor Zsolt and Orosz, Miklós and Czuriga-Kovács, Katalin Réka and Magyar, Mária Tünde and Csiba, László and Oláh, László (2016) The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects. JOURNAL OF THE NEUROLOGICAL SCIENCES, 368. pp. 113-120. ISSN 0022-510X
Kapcsolat:
https://doi.org/10.1016/j.jns.2016.06.060
MTMT:3151388; doi:10.1016/j.jns.2016.06.060