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Bejelentkezés
Kapcsolat
Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF kappa B Activation and Suppress Growth of A375 Human Melanoma |
Tartalom: | http://real.mtak.hu/49745/ |
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Archívum: | MTA Könyvtár |
Gyűjtemény: |
Status = Published
Type = Article |
Cím: |
Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF kappa B Activation and Suppress Growth of A375 Human Melanoma
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Létrehozó: |
Marton, Annamária
Kusz, Erzsébet
Kolozsi, Csongor
Tubak, Vilmos
Zagotto, G.
Buzás, Krisztina
Vizler, Csaba
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Kiadó: |
International Institute of Anticancer Research (IIAR)
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Dátum: |
2016
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Téma: |
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolĂłgia
RL Dermatology / bőrgyógyászat
RM Therapeutics. Pharmacology / terápia, gyógyszertan
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Tartalmi leírás: |
Background/Aim: Constitutive activation of nuclear factor kappa-B (NF kappa B) is a hallmark of various cancer types, including melanoma. Chemotherapy may further increase tumour NF kappa B activity, a phenomenon that, in turn, exacerbates drug resistance. This study aimed at preliminary screening of a panel of aromatic aldehydes, including vanillin, for cytotoxicity and suppression of tumour cell NF kappa B activity. Materials and Methods: The cytotoxic and NF kappa B-inhibitory effects of 10 aromatic aldehydes, including vanillin, were investigated in cultured A375 human melanoma cells. Each compound was assayed alone and in combination with the model NF kappa B-activating drug doxorubicin. The most promising analogues were then tested alone and in combination with 4-hydroperoxycyclophosphamide in vitro, and with cyclophosphamide in mice bearing A375 xenografts. Results: The vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde exhibited cytotoxicity against cultured A375 cells, and inhibited doxorubicin-and 4-hydroperoxycyclophosphamide-induced NF kappa B activation. They also suppressed A375 cell growth in mice. Conclusion: o-vanillin and 2,4,6-trihydroxybenzaldehyde deserve further evaluation as potential anticancer drugs.
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Nyelv: |
angol
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Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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Formátum: |
text
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Azonosító: |
Marton, Annamária and Kusz, Erzsébet and Kolozsi, Csongor and Tubak, Vilmos and Zagotto, G. and Buzás, Krisztina and Vizler, Csaba (2016) Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF kappa B Activation and Suppress Growth of A375 Human Melanoma. Anticancer Research, 36 (11). pp. 5743-5750. ISSN 0250-7005 (print), 1791-7530 (online)
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Kapcsolat: |
MTMT:3157889; doi:10.21873/anticanres.11157
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