Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer

Metaadatok

Tartalom:	http://real.mtak.hu/49741/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer
Létrehozó:	KovÃ¡cs, DÃ¡vid SzÅ‘ke, Krisztina Igaz, NÃ³ra Spengler, Gabriella MolnÃ¡r, JÃ³zsef MadarÃ¡sz, DÃ¡niel RÃ¡zga, Zsolt KÃ³nya, ZoltÃ¡n Boros, Imre MiklÃ³s CsontnÃ© Kiricsi, MÃ³nika
Kiadó:	Elsevier
Dátum:	2016
Téma:	QH3011 Biochemistry / biokÃ©mia QH3015 Molecular biology / molekulÃ¡ris biolÃ³gia QR Microbiology / mikrobiolÃ³gia QR180 Immunology / immunolÃ³gia RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolÃ³gia
Tartalmi leírás:	Abstract The emergence of multidrug resistant (MDR) cancer phenotypes dramatically attenuates the efficiency of antineoplastic drug treatments often leading to the failure of chemotherapy. Therefore there is an urgent need to engineer new therapeutically useful agents and propose innovative approaches able to defeat resistant cancer cells. Although the remarkable anti-cancer features of silver nanoparticles (AgNPs) have already been delineated their impact on MDR cancer has never been investigated. Herein, we report that AgNPs have a notable anti-proliferative effect and induce apoptosis mediated cell death both in drug sensitive and in MDR cancer cells. Furthermore we show evidence that AgNPs exert an inhibitory action on the efflux activity of MDR cancer cells which feature could be exploited to enhance drug accumulation. We verified synergistic interactions of AgNPs with six different antineoplastic agents on drug resistant cells which emphasizes the excellent potential of AgNPs as combinational partners in the chemotherapy of MDR cancer.
Nyelv:	angol
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text
Azonosító:	http://real.mtak.hu/49741/1/KovacsNanomed.pdf KovÃ¡cs, DÃ¡vid and SzÅ‘ke, Krisztina and Igaz, NÃ³ra and Spengler, Gabriella and MolnÃ¡r, JÃ³zsef and MadarÃ¡sz, DÃ¡niel and RÃ¡zga, Zsolt and KÃ³nya, ZoltÃ¡n and Boros, Imre MiklÃ³s and CsontnÃ© Kiricsi, MÃ³nika (2016) Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer. NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE, 12 (3). pp. 601-610. ISSN 1549-9634
Kapcsolat:	http://real.mtak.hu/49741/ http://dx.doi.org/10.1016/j.nano.2015.10.015 MTMT:2990683; doi:10.1016/j.nano.2015.10.015