Indispensability of Horizontally Transferred Genes and Its Impact on Bacterial Genome Streamlining
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Tartalom: http://real.mtak.hu/49738/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Indispensability of Horizontally Transferred Genes and Its Impact on Bacterial Genome Streamlining
Létrehozó:
Karcagi, IldikĂł
Draskovits, Gábor
Umenhoffer, Kinga
Fekete, Gergely
Kovács, Károly
MĂ©hi, Orsolya Katinka
BalikĂł, Gabriella
Szappanos, Balázs
Győrfy, Zsuzsanna
Fehér, Tamás
Bogos, Balázs
Pál, Csaba
Pósfai, György
Papp, Balázs
Kiadó:
Oxford University Press
Dátum:
2016
Téma:
QH3011 Biochemistry / biokémia
Tartalmi leírás:
Why are certain bacterial genomes so small and compact? The adaptive genome streamlining hypothesis posits that selection acts to reduce genome size because of themetabolic burden of replicating DNA. To reveal the impact of genome streamlining on cellular traits, we reduced the Escherichia coli genome by up to 20% by deleting regions which have been repeatedly subjects of horizontal transfer in nature. Unexpectedly, horizontally transferred genes not only confer utilization of specific nutrients and elevate tolerance to stresses, but also allow efficient usage of resources to build new cells, and hence influence fitness in routine and stressful environments alike. Genome reduction affected fitness not only by gene loss, but also by induction of a general stress response. Finally, we failed to find evidence that the advantage of smaller genomes would be due to a reduced metabolic burden of replicating DNA or a link with smaller cell size. We conclude that as the potential energetic benefit gained by deletion of short genomic segments is vanishingly small compared with the deleterious side effects of these deletions, selection for reduced DNA synthesis costs is unlikely to shape the evolution of small genomes.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Karcagi, Ildikó and Draskovits, Gábor and Umenhoffer, Kinga and Fekete, Gergely and Kovács, Károly and Méhi, Orsolya Katinka and Balikó, Gabriella and Szappanos, Balázs and Győrfy, Zsuzsanna and Fehér, Tamás and Bogos, Balázs and Pál, Csaba and Pósfai, György and Papp, Balázs (2016) Indispensability of Horizontally Transferred Genes and Its Impact on Bacterial Genome Streamlining. MOLECULAR BIOLOGY AND EVOLUTION, 33 (5). pp. 1257-1269. ISSN 0737-4038
Kapcsolat:
MTMT:3066805; doi:10.1093/molbev/msw009