Microbleeds may expand acutely after traumatic brain injury
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Tartalom: http://real.mtak.hu/48834/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published


Type = Article
Cím:
Microbleeds may expand acutely after traumatic brain injury
Létrehozó:
TĂłth, Arnold
Kovács, Noémi
Tamás, Viktoria
Kornyei, Balint
Nagy, Máté
Horváth, Andrea
Rostás, Tamás
Bogner, PĂ©ter
Janszky, JĂłzsef VladimĂ­r
Dóczi, Tamás
Büki, András
Schwarcz, Attila
Kiadó:
Elsevier
Dátum:
2016-03-23
Téma:
R1 Medicine (General) / orvostudomány általában
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Tartalmi leírás:
BACKGROUND AND PURPOSE
Susceptibility weighted imaging (SWI) is a very sensitive tool for the detection of microbleeds in traumatic brain injury (TBI). The number and extent of such traumatic microbleeds (TMBs) have been shown to correlate with the severity of the injury and the clinical outcome. However, the acute dynamics of TMBs have not been revealed so far. Since TBI is known to constitute dynamic pathological processes, we hypothesized that TMBs are not constant in their appearance, but may progress acutely after injury.
MATERIALS AND METHODS
We present here five closed moderate/severe (Glasgow coma scale≤13) TBI patients who underwent SWI very early (average=23.4 h), and once again a week (average=185.8 h) after the injury. The TMBs were mapped at both time points by a conventional radiological approach and their numbers and volumes were measured with manual tracing tools by two observers. TMB counts and extents were compared between time points.
RESULTS
TMBs were detected in four patients, three of them displaying an apparent TMB change. In these patients, TMB confluence and apparent growth were detected in the corpus callosum, coronal radiation or subcortical white matter, while unchanged TMBs were also present. These changes caused a decrease in the TMB count associated with an increase in the overall TMB volume over time.
CONCLUSION
We have found a compelling evidence that diffuse axonal injury-related microbleed development is not limited strictly to the moment of injury: the TMBs might expand in the acute phase of TBI. The timing of SWI acquisition may be relevant for optimizing the prognostic utility of this imaging biomarker.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Tóth, Arnold and Kovács, Noémi and Tamás, Viktoria and Kornyei, Balint and Nagy, Máté and Horváth, Andrea and Rostás, Tamás and Bogner, Péter and Janszky, József Vladimír and Dóczi, Tamás and Büki, András and Schwarcz, Attila (2016) Microbleeds may expand acutely after traumatic brain injury. Neuroscience letters, 617. pp. 207-212. ISSN 1872-7972
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