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Kapcsolat
NaBH4 – a novel method for the deprotection of Nω-nitro-arginine |
Tartalom: | http://real.mtak.hu/46519/ |
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Archívum: | MTA Könyvtár |
Gyûjtemény: |
Status = Published
Type = Article |
Cím: |
NaBH4 – a novel method for the deprotection of Nω-nitro-arginine
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Létrehozó: |
Sebestyén, Mónika
Kóczán, György
Csámpai, Antal
Hudecz, Ferenc
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Kiadó: |
Pergamon Press
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Dátum: |
2016
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Téma: |
QD04 Organic chemistry / szerves kémia
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Tartalmi leírás: |
The selective deprotection of Nω-nitro-arginine derivatives represents a major preparative challenge. This problem can be circumvented by the use of catalytic hydrogenation, but often high pressure, elevated temperature, and/or long reaction times are needed. In certain cases hydrogenation is not suitable, for example, small-scale reactions, parallel synthesis, or due to selectivity issues. Herein, we demonstrate for the first time, the use of NaBH4 in the presence of a metal ion catalyst for the removal of the Nω-nitro moiety under simple, ‘open-vessel’ conditions. This process using NaBH4 does not remove the benzyloxy-carbonyl-protecting group; thus the method is orthogonal for this protecting scheme.
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Nyelv: |
magyar
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Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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Formátum: |
text
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Azonosító: |
Sebestyén, Mónika and Kóczán, György and Csámpai, Antal and Hudecz, Ferenc (2016) NaBH4 – a novel method for the deprotection of Nω-nitro-arginine. TETRAHEDRON LETTERS, 57. pp. 546-548. ISSN 0040-4039
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Kapcsolat: |
10.1016/j.tetlet.2015.12.081
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