NDA@SZTAKI

Transient compartmentalization of RNA replicators prevents extinction due to parasites

Matsumura, Shigeyoshi

Kun, Ádåm

Ryckelynck, Michael

Coldren, Faith

SzilĂĄgyi, AndrĂĄs

Jossinet, Fabrice

Rick, Christian

Nghe, Philippe

SzathmĂĄry, EĂśrs

Griffiths, Andrew

American Association for the Advancement of Science

2016-12-09

QH301 Biology / biolĂłgia

QH359-425 Evolution (Biology) / evolĂşciĂł

QH426 Genetics / genetika, ĂśrĂśklĂŠstan

The appearance of molecular replicators (molecules that can be copied) was probably a critical step in the origin of life. However, parasitic replicators would take over and would have prevented life from taking off unless the replicators were compartmentalized in reproducing protocells. Paradoxically, control of protocell reproduction would seem to require evolved replicators.We show here that a simpler population structure, based on cycles of transient compartmentalization (TC) and mixing of RNA replicators, is sufficient to prevent takeover by parasitic mutants.TC tends to select for ensembles of replicators that replicate at a similar rate, including a diversity of parasites that could serve as a source of opportunistic functionality. Thus,TC in natural, abiological compartments could have allowed life to take hold.

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/46471/1/Science_accepted_Szathmary_Eors...

Matsumura, Shigeyoshi and Kun, Ádåm and Ryckelynck, Michael and Coldren, Faith and Szilågyi, Andrås and Jossinet, Fabrice and Rick, Christian and Nghe, Philippe and Szathmåry, EÜrs and Griffiths, Andrew (2016) Transient compartmentalization of RNA replicators prevents extinction due to parasites. SCIENCE, 354 (6317). pp. 1293-1296. ISSN 0036-8075

http://real.mtak.hu/46471/

http://science.sciencemag.org/content/354/6317/1293

10.1126/science.aag1582

294332 and 225167

info:eu-repo/semantics/openAccess