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Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015

BĂĄnyai, KrisztiĂĄn

TĂłthnĂŠ BistyĂĄk, Andrea

Thuma, Ákos

Gyuris, Éva

Ursu, Krisztina

Marton, Szilvia

Farkas, Szilvia L.

HortobĂĄgyi, EleonĂłra

Bacsadi, Árpåd

Dån, Ádåm

Elsevier

2016

QR355 Virology / vĂ­ruskutatĂĄs

Highly pathogenic avian in
fl
uenza (HPAI) A virus H5N8 was detected in far east Asian countries during 2014 and
emerged in late 2014 in European countries. Hungary reported a HPAI A(H5N8) outbreak during late winter of
2015 at a Pekin duck fattening facility. Epidemiologic monitoring was extended to holdings in neighboring
areas and nearby habitats used by wild birds but failed to identify the source of infection. In addition to respira-
tory symptoms, the affected birds showed lethargy and neuronal signs, including torticollis. Consistent with this
fi
nding, in
fl
uenza A virus antigen was detected in large quantity in the brain. Molecular analysis of the identi
fi
ed
strain showed very close genetic relationship (and
N
99% nucleotide sequence identity) with co-circulating HPAI
A(H5N8) strains. A number of unique or rarely detected amino acid changes was detected in the HA (T220I,
R512G), the M2 (I39M), the NA (T211I), the NS1 (P85T), and the PB2 (I261V) proteins of the Hungarian strain.
Further studies are needed to demonstrate whether any of these mutations can be linked to neuroinvasiveness
and neurovirulence in ducks.

magyar

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/46106/1/influenza.pdf

Bányai, Krisztián and Tóthné Bistyák, Andrea and Thuma, Ákos and Gyuris, Éva and Ursu, Krisztina and Marton, Szilvia and Farkas, Szilvia L. and Hortobágyi, Eleonóra and Bacsadi, Árpád and Dán, Ádám (2016) Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015. INFECTION, GENETICS AND EVOLUTION (43). pp. 418-423. ISSN 1567-1348

http://real.mtak.hu/46106/