A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians
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Tartalom: http://real.mtak.hu/41515/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians
Létrehozó:
SzabĂł, KornĂŠlia
PolyĂĄnka, Hilda
Kiricsi, Ágnes
RĂŠvĂŠsz, MĂłnika
VĂłna, Ida
SzabĂł, Zsolt
Bella, Zsolt
Kadocsa, Edit
KemĂŠny, Lajos
SzĂŠll, MĂĄrta
Hirschberg, Andor
Kiadó:
Elsevier Inc.
Dátum:
2015-11
Téma:
RF Otorhinolaryngology / orr-, fĂźl-, gĂŠgĂŠszet
Tartalmi leírás:
Inflammation plays a central role in the pathogenesis of chronic rhinosinusitis (CRS), and TNFÎą is a key pro-inflammatory cytokine in the pathogenesis of this disease. In our previous studies we showed that the TNFA -308A allele is a genetic predisposition factor in a subgroup of aspirin-sensitive (ASA+) CRS patients suffering from nasal polyps (NP) in the Hungarian population.
To determine whether the TNF -308A allele or the presence of a complex, extended ancestral haplotype (8.1AH) located on chromosome 6 is responsible for the previously observed genetic effect, we performed a case-control study for examining the frequency of 8.1AH carriers in controls and in subgroups of CRS patients.
Our novel observations demonstrate that the presence of the 8.1AH may be responsible for the development of severe forms of CRS (CRSwNP, ASA+) and strengthen the clinical observation that CRS patients can be classified into clinically and genetically different subgroups.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Szabó, KornÊlia and Polyånka, Hilda and Kiricsi, Ágnes and RÊvÊsz, Mónika and Vóna, Ida and Szabó, Zsolt and Bella, Zsolt and Kadocsa, Edit and KemÊny, Lajos and SzÊll, Mårta and Hirschberg, Andor (2015) A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians. Human Immunology, 76 (11). pp. 858-862. ISSN 0198-8859
Kapcsolat:
doi: 10.1016/j.humimm.2015.09.048