Differential sensitivity of the species of Candida parapsilosis sensu lato complex against statins
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Tartalom: http://real.mtak.hu/41482/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Differential sensitivity of the species of Candida parapsilosis sensu lato complex against statins
Létrehozó:
Szenzenstein, Judit
Gácser, Attila
GrĂłzer, Zsuzsanna
Farkas, Zoltán
Nagy, Katalin
Vágvölgyi, Csaba
Márki-Zay, János
Pfeiffer, Ilona
Kiadó:
Springer
Dátum:
2013-10
Téma:
QR Microbiology / mikrobiolĂłgia
Tartalmi leírás:
Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis are human fungal pathogens with clinical importance. The recently reclassified three closely related species have significant variation in virulence, clinical prevalence and susceptibility characteristics to different antifungal compounds. The aim of this study was to investigate the in vitro activity of atorvastatin and fluvastatin against C. metapsilosis, C. orthopsilosis and C. parapsilosis. Susceptibility tests showed that C. parapsilosis was the most sensitive while C. orthopsilosis was the least susceptible species to both drugs. On the basis of the differential sensitivity, we developed a simple, reliable and highly cost-effective plate assay to distinguish these closely related species. Applying this method, 54 isolates belonging to the C. parapsilosis sensu lato complex deposited in Szeged Microbial Collection could be sorted into the three species with 100 % probability.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Szenzenstein, Judit and Gácser, Attila and Grózer, Zsuzsanna and Farkas, Zoltán and Nagy, Katalin and Vágvölgyi, Csaba and Márki-Zay, János and Pfeiffer, Ilona (2013) Differential sensitivity of the species of Candida parapsilosis sensu lato complex against statins. Mycopathologia, 176 (3-4). pp. 211-7. ISSN 1573-0832
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