Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited bz short propriospinal ascending inputs
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Tartalom: http://real.mtak.hu/41456/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited bz short propriospinal ascending inputs
Létrehozó:
Antal, ZsĂłfia
Luz, Liliana L.
Safronov, Boris V.
Antal, MiklĂłs
SzĂĽcs, PĂ©ter
Kiadó:
Springer Verlag
Dátum:
2015-04
Téma:
QP Physiology / Ă©lettan
Tartalmi leírás:
The role of spinal dorsal horn propriospinal
connections in nociceptive processing is not yet estab-
lished. Recently described, rostrocaudally oriented axon
collaterals of lamina I projection and local-circuit neurons
(PNs and LCNs) running in the dorsolateral funiculus
(DLF) may serve as the anatomical substrate for interseg-
mental processing. Putative targets of these axons include
lateral dendrites of superficial dorsal horn neurons, in-
cluding PNs, and also neurons in the lateral spinal nucleus
(LSN) that are thought to be important integrator units
receiving, among others, visceral sensory information.
Here we used an intact spinal cord preparation to study
intersegmental connections within the lateral part of the
superficial dorsal horn. We detected brief monosynaptic
and prolonged polysynaptic excitation of lamina I and LSN
neurons when stimulating individual dorsal horn neurons
located caudally, even in neighboring spinal cord seg-
ments. These connections, however, were infrequent. We
also revealed that some projection neurons outside the dorsal grey matter and in the LSN have distinct, previously
undescribed course of their projection axon. Our findings
indicate that axon collaterals of lamina I PNs and LCNs in
the DLF rarely form functional connections with other
lamina I and LSN neurons and that the majority of their
targets are on other elements of the dorsal horn. The unique
axon trajectories of neurons in the dorsolateral aspect of the
spinal cord, including the LSN do not fit our present un-
derstanding of midline axon guidance and suggest that their
function and development differ from the neurons inside
lamina I. These findings emphasize the importance of un-
derstanding the connectivity matrix of the superficial dorsal
horn in order to decipher spinal sensory information
processing.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Antal, ZsĂłfia and Luz, Liliana L. and Safronov, Boris V. and Antal, MiklĂłs and SzĂĽcs, PĂ©ter (2015) Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited bz short propriospinal ascending inputs. Brains Structure and Function. ISSN 1869-2653
Kapcsolat:
DOI 10.1007/s00429-015-1046-3