Investigation of Skin Barrier Functions and Allergic Sensitization in Patients with Hyper-IgE Syndrome
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Tartalom: http://real.mtak.hu/41218/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Investigation of Skin Barrier Functions and Allergic Sensitization in Patients with Hyper-IgE Syndrome
Létrehozó:
Mócsai, Gábor
Gáspár, Krisztián
Dajnoki, Zsolt
Tóth, Beáta
Gyimesi, Edit
Bíró, Tamás
Maródi, László
Szegedi, Andrea
Kiadó:
Springer
Dátum:
2015-10-09
Téma:
RL Dermatology / bőrgyógyászat
Tartalmi leírás:
Purpose Hyper-IgE syndrome (HIES) is a severe primary immunodeficiency,
characterized by increased serum IgE levels
as well as recurrent infections and atopic dermatitis (AD)-like
skin lesions. AD is a chronic inflammatory skin disease with
immunologic alterations (Th2-Th22 polarization) and characteristic
skin barrier dysfunctions. Our aim was to investigate
physicochemical skin barrier alterations and allergic sensitization
in STAT3-HIES patients in order to explore whether skin
barrier dysfunction can play a role in the eczematoid skin
lesions in these patients.
Methods In our experiments STAT3 and FLG mutation analyses
were performed in STAT3-HIES (n=7) and AD (n=49)
patients. Laboratory parameters (LDH and Eos counts), immunologic
alterations (Th17 cell counts), allergic sensitization
(total and specific IgE levels, skin prick tests, and medical
history records), skin barrier changes [transepidermal water
loss (TEWL), skin pH], serum and stratum corneum thymic
stromal lymphopoietin (TSLP) levels were also examined.
Results Impaired Th17 cell numbers, but normal physicochemical
barrier functions, as well as serum and stratum
corneum TSLP levels, were found in STAT3-HIES, while
these parameters were significantly altered in AD patients.
Allergic sensitization was detected in nearly all AD patients,
while no signs of sensitization occurred in STAT3-HIES.
Conclusions Our study demonstrated that the skin barrier
functions of STAT3-HIES patients are not damaged and they
differ significantly from the altered skin barrier functions of
AD patients. Awell-functioning physicochemical skin barrier
may be one of the explanations on the contradiction between
the extremely high total IgE levels and the lack of allergic
sensitization in these patients. Our study underlines the importance
of skin barrier in the development of allergic
sensitization.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Mócsai, Gábor and Gáspár, Krisztián and Dajnoki, Zsolt and Tóth, Beáta and Gyimesi, Edit and Bíró, Tamás and Maródi, László and Szegedi, Andrea (2015) Investigation of Skin Barrier Functions and Allergic Sensitization in Patients with Hyper-IgE Syndrome. Journal of clinical immunology (35). pp. 681-688. ISSN 1573-2592
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