Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish
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Tartalom: http://real.mtak.hu/41183/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish
Létrehozó:
Appenzeller-Herzog, Christian
Bánhegyi, Gabor
Bogeski, Ivan
Davies, Kelvin J A
Delaunay-Moisan, Agnès
Forman, Henry Jay
Görlach, Agnes
Kietzmann, Thomas
Laurindo, Francisco
Margittai, Eva
Meyer, Andreas J
Riemer, Jan
RĂĽtzler, Michael
Simmen, Thomas
Sitia, Roberto
Toledano, Michel B
Touw, Ivo P
Kiadó:
Elsevier
Dátum:
2016-05
Téma:
Q1 Science (General) / természettudomány általában
Tartalmi leírás:
Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Appenzeller-Herzog, Christian and Bánhegyi, Gabor and Bogeski, Ivan and Davies, Kelvin J A and Delaunay-Moisan, Agnès and Forman, Henry Jay and Görlach, Agnes and Kietzmann, Thomas and Laurindo, Francisco and Margittai, Eva and Meyer, Andreas J and Riemer, Jan and Rützler, Michael and Simmen, Thomas and Sitia, Roberto and Toledano, Michel B and Touw, Ivo P (2016) Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free radical biology & medicine, 94. pp. 157-160. ISSN 1873-4596
Kapcsolat:
https://doi.org/10.1016/j.freeradbiomed.2016.02.030