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Kapcsolat
A pH dependent delivery of mesalazine from polymer coated and drug-loaded SBA-16 systems |
Tartalom: | http://real.mtak.hu/40514/ |
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Archívum: | MTA Könyvtár |
Gyűjtemény: |
Status = Published
Type = Article |
Cím: |
A pH dependent delivery of mesalazine from polymer coated and drug-loaded SBA-16 systems
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Létrehozó: |
Trendafilova, Ivalina
Szegedi, Ăgnes
Yoncheva, Krassimira
Shestakova, Pavletta
MihĂĄly, Judith
RistiÄ, Alenka
Konstantinov, Spiro
Popova, Margarita
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Kiadó: |
Elsevier
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Dátum: |
2016
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Téma: |
QD Chemistry / kĂŠmia
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Tartalmi leírás: |
SBA-16 silica was synthesized and modified by post-synthesis method with amino groups. Wet milling in acidic media was applied for loading of poorly soluble drug mesalazine (5-aminosalicylic acid -5-ASA) in different drug/carrier ratios (1: 1; 0.75: 1; 0.5: 1; 0.25: 1). The parent and drug loaded mesoporous silicas were characterized by XRD, TEM, N-2 physisorption, thermal analysis, FT-IR and solid state NMR spectroscopy. The drug loaded mesoporous systems were single-coated with Eudragit S or double-coated with Eudragit S and Eudragit RL. The polymer coating significantly modified the rate of mesalazine release from SBA-16NH(2) materials. Applying the double coating method makes possible the sustained delivery of the drug in the intestinal area avoiding the burst release in the gastric fluid. The functionalized, polymer coated mesoporous system could be considered an appropriate oral delivery system for mesalazine. In addition, reduction of mesalazine cytotoxicity on epithelial cells could be achieved by its loading into mesoporous silica particles. (C) 2015 Elsevier B.V. All rights reserved.
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Nyelv: |
angol
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Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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Formátum: |
text
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Azonosító: |
Trendafilova, Ivalina and Szegedi, Ăgnes and Yoncheva, Krassimira and Shestakova, Pavletta and MihĂĄly, Judith and RistiÄ, Alenka and Konstantinov, Spiro and Popova, Margarita (2016) A pH dependent delivery of mesalazine from polymer coated and drug-loaded SBA-16 systems. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 81. pp. 75-81. ISSN 0928-0987
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Kapcsolat: |
MTMT:3118032; doi:10.1016/j.ejps.2015.10.003
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