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A pH dependent delivery of mesalazine from polymer coated and drug-loaded SBA-16 systems

  • Metaadatok
Tartalom: http://real.mtak.hu/40514/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Published

Type = Article
Cím:
A pH dependent delivery of mesalazine from polymer coated and drug-loaded SBA-16 systems
Létrehozó:
Trendafilova, Ivalina
Szegedi, Ágnes
Yoncheva, Krassimira
Shestakova, Pavletta
MihĂĄly, Judith
Ristić, Alenka
Konstantinov, Spiro
Popova, Margarita
Kiadó:
Elsevier
Dátum:
2016
Téma:
QD Chemistry / kĂŠmia
Tartalmi leírás:
SBA-16 silica was synthesized and modified by post-synthesis method with amino groups. Wet milling in acidic media was applied for loading of poorly soluble drug mesalazine (5-aminosalicylic acid -5-ASA) in different drug/carrier ratios (1: 1; 0.75: 1; 0.5: 1; 0.25: 1). The parent and drug loaded mesoporous silicas were characterized by XRD, TEM, N-2 physisorption, thermal analysis, FT-IR and solid state NMR spectroscopy. The drug loaded mesoporous systems were single-coated with Eudragit S or double-coated with Eudragit S and Eudragit RL. The polymer coating significantly modified the rate of mesalazine release from SBA-16NH(2) materials. Applying the double coating method makes possible the sustained delivery of the drug in the intestinal area avoiding the burst release in the gastric fluid. The functionalized, polymer coated mesoporous system could be considered an appropriate oral delivery system for mesalazine. In addition, reduction of mesalazine cytotoxicity on epithelial cells could be achieved by its loading into mesoporous silica particles. (C) 2015 Elsevier B.V. All rights reserved.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Trendafilova, Ivalina and Szegedi, Ágnes and Yoncheva, Krassimira and Shestakova, Pavletta and Mihály, Judith and Ristić, Alenka and Konstantinov, Spiro and Popova, Margarita (2016) A pH dependent delivery of mesalazine from polymer coated and drug-loaded SBA-16 systems. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 81. pp. 75-81. ISSN 0928-0987
Kapcsolat:
MTMT:3118032; doi:10.1016/j.ejps.2015.10.003