NDA@SZTAKI

Preserved intention maintenance and impaired execution of prospective memory responses in schizophrenia: evidence from an event-based prospective memory study

Demeter, Gyula

Szendi, IstvĂĄn

DomjĂĄn, NĂłra

JuhĂĄsz, Marianna

Greminger, NĂłra

Szőllősi, Ágnes

RacsmĂĄny, MihĂĄly

Frontiers

2016

BF13 Memory and learning / emlĂŠkezet, tanulĂĄs

RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkĂłrtan, neurolĂłgia, pszichiĂĄtria

Executive system dysfunction and impaired prospective memory (PM) are widely
documented in schizophrenia. However, it is not yet clarified which components of
PM function are impaired in this disorder. Two plausible target components are the
maintenance of delayed intentions and the execution of PM responses. Furthermore,
it is debated whether the impaired performance on frequently used executive tasks
is associated with deficit in PM functions. The aim of our study was twofold. First,
we aimed to investigate the specific processes involved in event-based PM function,
mainly focusing on difference between maintenance of intention and execution of PM
responses. Second, we aimed to unfold the possible connections between executive
functions, clinical symptoms, and PM performance. An event-based PM paradigm
was applied with three main conditions: baseline (with no expectation of PM stimuli,
and without PM stimuli), expectation condition (participants were told that PM stimuli
might occur, though none actually did), and execution condition (participants were
told that PM stimuli might occur, and PM stimuli did occur). This procedure allowed
us to separately investigate performances associated with intention maintenance and
execution of PM responses. We assessed working memory and set-shifting executive
functions by memory span tasks and by the Wisconsin Card Sorting Test (WCST),
respectively. Twenty patients diagnosed with schizophrenia and 20 healthy control
subjects (matched according to age and education) took part in the study. It was
hypothesized that patients would manifest different levels of performance in the
expectation and execution conditions of the PM task. Our results confirmed that the
difference between baseline performance and performance in the execution condition
(execution cost) was significantly larger for participants diagnosed with schizophrenia
in comparison with matched healthy control group. However, this difference was not
observed in the expectation condition. The PM performance in the execution condition
was correlated with impaired executive functions in schizophrenia. Specifically, the size ofexecutioncostpositivelycorrelatedwithpercentofperseverativeerrorscommittedonWCSTbythepatientgroup.Ourresultssuggestthatmaintenanceofdelayedintentionsisunimpairedinschizophrenia,whereastheimpairmentinexecutionofPMresponsesisassociatedwithset-shiftingdeficit.
Keywords:schizophrenia,prospectivememory,executivefunctions,intentionmaintenance,negativesymptoms

magyar

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/40477/1/Frontiers%20in%20Psychology_Pre...

Demeter, Gyula and Szendi, István and Domján, Nóra and Juhász, Marianna and Greminger, Nóra and Szőllősi, Ágnes and Racsmány, Mihály (2016) Preserved intention maintenance and impaired execution of prospective memory responses in schizophrenia: evidence from an event-based prospective memory study. FRONTIERS IN PSYCHOLOGY, 7:593. pp. 1-10. ISSN 1664-1078

http://real.mtak.hu/40477/

http://dx.doi.org/10.3389/fpsyg.2016.00593

doi: 10.3389/fpsyg.2016.00593