NDA@SZTAKI

Neuropsychological outcomes of subthalamic nucleus deep brain stimulation in Parkinson’s disease.

Demeter, Gyula

Pajkossy, PĂŠter

Szőllősi, Ágnes

Lukåcs, Ágnes

ValĂĄlik, IstvĂĄn

RacsmĂĄny, MihĂĄly

2016-01

BF Psychology / lĂŠlektan

BF12 Attention / figyelem

BF13 Memory and learning / emlĂŠkezet, tanulĂĄs

RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkĂłrtan, neurolĂłgia, pszichiĂĄtria

RD Surgery / sebĂŠszet

Despite the improvement of motor symptoms in Parkinson’s disease after deep brain
stimulation (DBS) of the subthalamic nucleus (STN) is well documented, there are open
questions regarding its impact on cognitive functions. The aim of the present study was to
asses the effect of bilateral DBS of the STN on executive and memory functions in PD
patients using an unstimulated PD control group matched on age, education, disease duration,
motor symptoms, medication and DBS indication. All PD patients included in study fulfilled
the UK Parkinson’s Disease Society Brain Bank clinical diagnostic criteria for PD. Thirteen
PD patients with DBS implantation (DBS group) and 15 PD wait-listed patients (control
group) participated in the study. Motor symptoms were assessed by the Unified Parkinson’s
Rating Scale (UPDRS) motor score, anxiety by the State and Trait Anxiety Inventory (STAI)
and depression by the Beck Depression Inventory (BDI). A neuropsychological battery was
used to assess cognitive functions, including general mental ability (Mini Mental State
Examination), verbal (digit span) and spatial short-term memory (Corsi block-tapping task),
working memory (n-back task) and executive functions (phonemic and semantic verbal
fluency, Stroop task, Trail Making B task). Each task was administered twice: before and after
surgery in the DBS group with the stimulators on and with a similar time interval between the
two task-administration points in the control group. There was no significant difference
between the DBS and the control groups’ performance in tasks measuring short-term verbal,
spatial and working memory and executive functions assessed by the Trail Making B and the
Stroop Tasks. The DBS group showed a significant decline on the semantic verbal fluency
task after surgery compared to its own baseline level (p < .05). The findings are discussed
considering different possible effects of the STN DBS on frontosriatal networks.
Keywords: Parkinson Disease, deep brain stimulation, executive function, memory

magyar

Conference or Workshop Item

PeerReviewed

info:eu-repo/semantics/conferenceObject

text

http://real.mtak.hu/40468/1/IBRO_Abstract_Demeter%20et%20al...

Demeter, Gyula and Pajkossy, Péter and Szőllősi, Ágnes and Lukács, Ágnes and Valálik, István and Racsmány, Mihály (2016) Neuropsychological outcomes of subthalamic nucleus deep brain stimulation in Parkinson’s disease. In: IBRO Workshop, 21-22 Jan 2016, Budapest.

http://real.mtak.hu/40468/