NDA@SZTAKI

Multiple inclusion complex formation of protonated ellipticine with cucurbit[8]uril: Thermodynamics and fluorescence properties

Miskolczy, Zsombor

Biczók, László

Jablonkai, István

Taylor & Francis

2016

QD02 Physical chemistry / fizikai kémia

The encapsulation of protonated ellipticine (EH+) in the cavity of cucurbit[8]uril (CB8) was
studied in water at pH 4 with spectrophotometric, fluorescence spectroscopic and isothermal
calorimetric measurements. The formation of three types of inclusion complexes was observed
depending on the host and guest concentrations. Not only one but also two EH+ was capable of
encapsulation in CB8 in 37 ÎĽM EH+ solution and the thermodynamics of the binding steps were
revealed. The produced very stable complexes showed markedly different absorption and
fluorescence properties. When large excess of CB8 was employed in dilute (0.49 ÎĽM) EH+
solution, sequential binding of two CB8 occurred to the monomer alkaloid bringing about a
substantial alteration in the fluorescence decay kinetics. The driving force of the 1:2 guest:host
complex formation was much lower than that of 1:1 encapsulation.

magyar

Article

PeerReviewed

info:eu-repo/semantics/article

text

http://real.mtak.hu/40371/1/Revised%20Manuscript2.pdf

Miskolczy, Zsombor and Biczók, László and Jablonkai, István (2016) Multiple inclusion complex formation of protonated ellipticine with cucurbit[8]uril: Thermodynamics and fluorescence properties. Supramolecular Chemistry. ISSN 1061-0278 (In Press)

http://real.mtak.hu/40371/