Expression pattern of invasion-related molecules in the peritumoral brain (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

Expression pattern of invasion-related molecules in the peritumoral brain

Metaadatok

Tartalom:	http://real.mtak.hu/40366/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	Expression pattern of invasion-related molecules in the peritumoral brain
Létrehozó:	Klekner, Ãlmos HutÃ³czki, GÃ¡bor Virga, JÃ³zsef RemÃ©nyi-PuskÃ¡r, Judit TÃ³th, Judit Scholtz, BeÃ¡ta CsÅ‘sz, Ã‰va KallÃ³, GergÅ‘ Steiner, LÃ¡szlÃ³ HortobÃ¡gyi, Tibor BognÃ¡r, LÃ¡szlÃ³
Kiadó:	Elsevier
Dátum:	2015-12
Téma:	RB Pathology / patolÃ³gia, kÃ³rtan RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkolÃ³gia
Tartalmi leírás:	OBJECTIVE: The effectiveness of therapy of intracerebral neoplasms is mainly influenced by the invasive behaviour of the tumour. The peritumoral invasion depends on the interaction between the tumour cells and the extracellular matrix (ECM) of the surrounding brain. The invading tumour cells induce change in the activity of proteases, synthases and expression of ECM-components. These alterations in the peritumoral ECM are in connection to the highly different invasiveness of gliomas and metastatic brain tumours. To understand the fairly modified invasive potential of anaplastic intracerebral tumours of different origin, the effect of tumour on the peritumoral ECM and alterations of invasion related ECM components in the peritumoral brain were evaluated. METHODS: For this reason the mRNA expression of 19 invasion-related molecules by quantitative reverse transcriptase polymerase chain reaction was determined in normal brain tissue (Norm), in the peritumoral brain tissue of glioblastoma (peri-GBM) and of intracerebral adenocarcinoma metastasis (peri-Met). To evaluate the translational expression of the investigated molecules protein levels were determined by targeted proteomic methods. RESULTS: Establishing the invasion pattern of the investigated tissue samples 8 molecules showed concordant difference at mRNA and protein levels in the peri-GBM and peri-Met, 11 molecules in the peri-Met and normal brain and 12 in the peri-GBM and normal brain comparison. CONCLUSION: Our results bring some ECM molecules into focus that probably play key role in arresting tumour cell invasion around the metastatic tumour, and also in the lack of impeding tumour cell migration in case of glioblastoma.
Nyelv:	magyar
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text
Azonosító:	http://real.mtak.hu/40366/1/Expression%20pattern%20of%20inv... Klekner, Ãlmos and HutÃ³czki, GÃ¡bor and Virga, JÃ³zsef and RemÃ©nyi-PuskÃ¡r, Judit and TÃ³th, Judit and Scholtz, BeÃ¡ta and CsÅ‘sz, Ã‰va and KallÃ³, GergÅ‘ and Steiner, LÃ¡szlÃ³ and HortobÃ¡gyi, Tibor and BognÃ¡r, LÃ¡szlÃ³ (2015) Expression pattern of invasion-related molecules in the peritumoral brain. Clinical Neurology and Neurosurgery, 139. pp. 138-143. ISSN 0303-8467
Kapcsolat:	http://real.mtak.hu/40366/ http://dx.doi.org/10.1016/j.clineuro.2015.09.017 doi:10.1016/j.clineuro.2015.09.017