Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits
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Tartalom: http://real.mtak.hu/40158/
Archívum: MTA Könyvtár
Gyűjtemény: Status = Submitted
Type = Article
Cím:
Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits
Létrehozó:
Szabó, András
SzabĂł-Fodor, Judit
FĂ©bel, Hedvig
MĂ©zes, MiklĂłs
Bajzik, Gábor
Kovács, Melinda
Kiadó:
Akadémiai Kiadó
Dátum:
2016
Téma:
SV Veterinary science / állatorvostudomány
Tartalmi leírás:
Weaned rabbits were fed diets contaminated with 2 mg/kg diet T-2 toxin alone, or 10 mg/kg
diet fumonisin B1 (FB1) alone, and both toxins in combination (2+10 mg / kg, resp.), as
compared to a toxin free control diet. Samplings were performed after 4 weeks (blood and
liver). Bodyweight of T-2-fed group was lower after 4 weeks; the liver weight was increased
dramatically (3-fold of control). Liver total phospholipids (PL) provided slight alterations in
the fatty acid (FA) composition; all three toxin treated groups showed decrease in palmitoleic
acid (C16:1 n7) proportion. In the liver mitochondrial PL FA composition margaric acid
(C17:0) proportion decreased in the separated toxin treatments, compared to the combined
setting. Oleic acid (C18:1 n9) proportion was increased and arachidonic acid (C20:4 n6) was
decreased in the by FB1-treated group, while docosapentaenoic acid (C22:5 n3) was decreased
in the separated treatments. The total monounsaturation was significantly higher in the FB1
group’s mitochondrial PL FA profile. After 4 weeks, all toxin treatments decreased the blood
plasma reduced glutathione and glutathione peroxidase activity, and FB1 increased the plasma
sphinganine/sphingosine ratio. Both mycotoxins seem to cross the hepatocellular and the
hepatic mitochondrial membrane, without drastic membrane disruption, as assessed from the
PL FA composition, but inducing detectable lipid peroxidation.
Nyelv:
magyar
Típus:
Article
NonPeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Szabó, András and Szabó-Fodor, Judit and Fébel, Hedvig and Mézes, Miklós and Bajzik, Gábor and Kovács, Melinda (2016) Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits. Acta Physiologica Hungarica. pp. 1-19. ISSN 0231-424X (Submitted)
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