Diastereomeric salt precipitation based resolution of ibuprofen by gas antisolvent method
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Tartalom: http://real.mtak.hu/38476/
Archívum: MTA Könyvtár
Gyűjtemény: Status = In Press

Type = Article
Cím:
Diastereomeric salt precipitation based resolution of ibuprofen by gas antisolvent method
Létrehozó:
Lőrincz, László
Bánsághi, György
Zsemberi, Máté
de Simon Brezmes, Sandra
Szilágyi, Imre Miklós
Madarász, János
Sohajda, Tamás
Székely, Edit
Kiadó:
Elsevier
Dátum:
2016
Téma:
TP Chemical technology / vegyipar, vegyészeti technológia
Tartalmi leírás:
We investigated the resolution and crystallization of ibuprofen with (R)-phenylethylamine based on diastereomeric salt formation using the supercritical gas antisolvent (GAS) method. Our goal was to study the effects of the operational
parameters (pressure, temperature and the carbon dioxide–organic solvent ratio) during an antisolvent resolution. The diastereomeric purity of the crystalline diastereomer salt (70–80% in a single step) was not affected by either parameter
in the range investigated. However, yields, and thus selectivity (a product of yield and diastereomeric purity) was strongly affected by pressure and the carbon dioxide–organic solvent ratio. Using methanol and ethanol, yield curves
as a function of the molar carbon dioxide–organic solvent ratio are the same for both solvents. By selecting appropriate parameters, the crystal habit (average crystal size and crystal size distribution) can be influenced. Some crystals
formed thin fibers with diameters in the micrometer range (1–3 µm), but certain parameters yielded shorter and thicker bladed crystals. At the optimal settings (10 MPa, 35 ◦C, 12.3 mol/mol carbon dioxide–methanol ratio) the resolvability
(0.444) slightly exceeded previously reported values using supercritical carbon dioxide, with a significant reduction in operating time.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Lőrincz, László and Bánsághi, György and Zsemberi, Máté and de Simon Brezmes, Sandra and Szilágyi, Imre Miklós and Madarász, János and Sohajda, Tamás and Székely, Edit (2016) Diastereomeric salt precipitation based resolution of ibuprofen by gas antisolvent method. JOURNAL OF SUPERCRITICAL FLUIDS. pp. 1-6. ISSN 0896-8446 (In Press)
Kapcsolat:
doi:10.1016/j.supflu.2016.07.021