Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies (NDA@SZTAKI, Nemzeti Digitális Adattár, National Digital Data Archive)

Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies

Metaadatok

Tartalom:	http://real.mtak.hu/36449/
Archívum:	MTA Könyvtár
Gyûjtemény:	Status = Published Type = Article
Cím:	Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies
Létrehozó:	NagynÃ© NaszÃ¡lyi, LÃvia MihÃ¡ly, Judith PolyÃ¡k, AndrÃ¡s Debreczeni, B. CsÃ¡szÃ¡r, B. SzigyÃ¡rtÃ³, Imola Csilla Wacha, AndrÃ¡s Ferenc CzÃ©gÃ©ny, Zsuzsanna PekkernÃ© Jakab, Emma KlÃ©bert, Szilvia DrotÃ¡r, Eszter Dabasi, Gabriella BÃ³ta, Attila Balogh, Lajos Kiss, Ã‰va
Kiadó:	Royal Society of Chemistry
Dátum:	2015
Téma:	QD Chemistry / kÃ©mia QH3020 Biophysics / biofizika RZ Other systems of medicine / orvostudomÃ¡ny egyÃ©b terÃ¼letei
Tartalmi leírás:	Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol-gel derived ZrO2 surface. After physico-chemical characterization of the native zirconia particles carboxyl and/or amine bearing drug molecules (d,l-[small alpha]-difluoromethylornithine - DFMO, ursolic acid - UA and doxorubicin - DOX) were adsorbed onto their surface, and the products were analyzed with Fourier-transform infrared spectroscopy (FTIR), thermogravimetry (TG), small-angle X-ray scattering (SAXS), fluorimetry and zeta potential vs. pH measurements. We have found that DOX complexes coordinatively unsaturated Zr4+ ions without dislocating them, while carboxyl-bearing drugs interact with basic surface Zr-OH sites eliminating some of the carbonate species. The adsorption of UA at the zirconia surface shifts considerably the isoelectric point of the surface and thus provides kinetic stability to the particles at physiological pH. An in vivo biodistribution study in two healthy dogs performed by SPECT/CT detection after 99mTc labeling of the nanocarriers has shown the possibility of drug delivery application.
Nyelv:	angol angol
Típus:	Article PeerReviewed info:eu-repo/semantics/article
Formátum:	text text
Azonosító:	http://real.mtak.hu/36449/1/ZrO2_JMaterChemB_2015.pdf http://real.mtak.hu/36449/2/ESM_Supplementary_LNN_short.pdf NagynÃ© NaszÃ¡lyi, LÃvia and MihÃ¡ly, Judith and PolyÃ¡k, AndrÃ¡s and Debreczeni, B. and CsÃ¡szÃ¡r, B. and SzigyÃ¡rtÃ³, Imola Csilla and Wacha, AndrÃ¡s Ferenc and CzÃ©gÃ©ny, Zsuzsanna and PekkernÃ© Jakab, Emma and KlÃ©bert, Szilvia and DrotÃ¡r, Eszter and Dabasi, Gabriella and BÃ³ta, Attila and Balogh, Lajos and Kiss, Ã‰va (2015) Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies. JOURNAL OF MATERIALS CHEMISTRY B, 3 (38). pp. 7529-7537. ISSN 2050-750X
Kapcsolat:	http://real.mtak.hu/36449/ http://dx.doi.org/10.1039/C5TB00832H MTMT:2946826; doi:10.1039/C5TB00832H